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Acute sleep loss al...
Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial
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- Brandao, Luiz Eduardo M. (author)
- Uppsala universitet,Hematologi,Transplantation och regenerativ medicin
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- Espes, Daniel, 1985- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Klinisk diabetologi och metabolism
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- Orzechowski Westholm, Jakub (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)
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- Martikainen, Teemu (author)
- Uppsala universitet,Transplantation och regenerativ medicin,Institutionen för medicinsk cellbiologi,Institutionen för immunologi, genetik och patologi
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- Westerlund, Nestori (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Popa, A. (author)
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Vogel, H. (author)
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Schurmann, A. (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Benedict, Christian, Docent, 1976- (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Cedernaes, Jonathan (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Transplantation och regenerativ medicin
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(creator_code:org_t)
- 2021-09-02
- 2022
- English.
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In: Journal of Sleep Research. - : Wiley. - 0962-1105 .- 1365-2869. ; 31:2
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Abstract
Subject headings
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- The hormone fibroblast growth factor 21 (FGF21) modulates tissue metabolism and circulates at higher levels in metabolic conditions associated with chronic sleep-wake disruption, such as type 2 diabetes and obesity. In the present study, we investigated whether acute sleep loss impacts circulating levels of FGF21 and tissue-specific production, and response pathways linked to FGF21. A total of 15 healthy normal-weight young men participated in a randomised crossover study with two conditions, sleep loss versus an 8.5-hr sleep window. The evening before each intervention, fasting blood was collected. Fasting, post-intervention morning skeletal muscle and adipose tissue samples underwent quantitative polymerase chain reaction and DNA methylation analyses, and serum FGF21 levels were measured before and after an oral glucose tolerance test. Serum levels of FGF21 were higher after sleep loss compared with sleep, both under fasting conditions and following glucose intake (similar to 27%-30%, p = 0.023). Fasting circulating levels of fibroblast activation protein, a protein which can degrade circulating FGF21, were not altered by sleep loss, whereas DNA methylation in the FGF21 promoter region increased only in adipose tissue. However, even though specifically the muscle exhibited transcriptional changes indicating adverse alterations to redox and metabolic homeostasis, no tissue-based changes were observed in expression of FGF21, its receptors, or selected signalling targets, in response to sleep loss. In summary, we found that acute sleep loss resulted in increased circulating levels of FGF21 in healthy young men, which may occur independent of a tissue-based stress response in metabolic peripheral tissues. Further studies may decipher whether changes in FGF21 signalling after sleep loss modulate metabolic outcomes associated with sleep or circadian disruption.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- adipose tissue
- circadian misalignment
- DNA methylation
- insulin
- resistance
- skeletal muscle
- tissue-specific
- insulin-secretion
- ppar-alpha
- fgf21
- obesity
- metabolism
- muscle
- liver
- pgc-1-alpha
- sensitivity
- physiology
- Neurosciences & Neurology
- adipose tissue
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brandao, Luiz Ed ...
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Espes, Daniel, 1 ...
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Orzechowski West ...
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Martikainen, Tee ...
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Westerlund, Nest ...
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Dickson, Suzanne ...
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Popa, A.
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Vogel, H.
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Schurmann, A.
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Benedict, Christ ...
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Cedernaes, Jonat ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Sleep ...
- By the university
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University of Gothenburg
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Stockholm University
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Uppsala University