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Lower plasma total ...
Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex
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- Andreou, D. (author)
- Karolinska Institutet
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Jorgensen, K. N. (author)
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Nerland, S. (author)
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Smelror, R. E. (author)
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Wedervang-Resell, K. (author)
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Johannessen, C. H. (author)
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Myhre, A. M. (author)
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Andreassen, O. A. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Agartz, I. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Journal of Psychiatric Research. - : Elsevier BV. - 0022-3956 .- 1879-1379. ; 144, s. 255-261
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Abstract
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- Schizophrenia is thought to be a neurodevelopmental disorder with neuronal migration, differentiation and maturation disturbances. Tau is a microtubule-associated protein with a crucial role in these processes. Lower circulating tau levels have been reported in adults with schizophrenia, but this association has not been investigated in adolescent psychosis. We aimed to test the hypotheses that a) adolescents with early-onset psychosis (EOP; age of onset <18 years) display lower plasma tau concentrations compared to healthy controls, and b) among patients with psychosis, tau levels are linked to structural brain measures associated with the microtubule-associated tau (MAPT) gene and psychosis. We included 37 adolescent patients with EOP (mean age 16.4 years) and 59 adolescent healthy controls (mean age 16.2 years). We investigated putative patient-control differences in plasma total tau concentrations measured by a Single molecule array (Simoa) immunoassay. We explored the correlations between tau and selected structural brain measures based on T1-weighted MRI scans processed in FreeSurfer v6.0. We found significantly lower plasma tau concentrations in patients compared to healthy controls (p = 0.017, partial eta-squared = 0.061). Tau was not associated with antipsychotic use or the antipsychotic dosage. Among patients but not healthy controls, tau levels were positively correlated with the cortical orbitofrontal surface area (p = 0.013, R-squared = 0.24). The results are suggestive of a tau-related neurodevelopmental disturbance in adolescent psychosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Tau
- Early-onset psychosis
- Adolescence
- MRI
- Orbitofrontal cortex
- cerebrospinal-fluid tau
- blood biomarkers
- cerebral-cortex
- frontotemporal dementia
- cognitive impairment
- schizophrenia
- disorder
- deficit
- bipolar
- injury
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andreou, D.
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Jorgensen, K. N.
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Nerland, S.
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Smelror, R. E.
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Wedervang-Resell ...
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Johannessen, C. ...
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show more...
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Myhre, A. M.
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Andreassen, O. A ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Agartz, I.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Journal of Psych ...
- By the university
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University of Gothenburg
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Karolinska Institutet