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Serum and cerebrosp...
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Paterson, Ross W
(author)
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-05-12
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Oxford University Press (OUP),2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/310869
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https://gup.ub.gu.se/publication/310869URI
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https://doi.org/10.1093/braincomms/fcab099DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (n=34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n=94) and without (n=24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14800pg/ml (400, 32400)], compared to those with encephalopathy [1410pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740pg/ml (507, 881)] and controls [872pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19.
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Benjamin, Laura A
(author)
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Mehta, Puja R
(author)
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Brown, Rachel L
(author)
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Athauda, Dilan
(author)
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
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Leckey, Claire A
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Ziff, Oliver J
(author)
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Heaney, Judith
(author)
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Heslegrave, Amanda J
(author)
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Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Checkley, Anna M
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Houlihan, Catherine F
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Mummery, Catherine J
(author)
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Lunn, Michael P
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Manji, Hadi
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Zandi, Michael S
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Keddie, Stephen
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Chou, Michael
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Vinayan Changaradil, Deepthi
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Solomon, Tom
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Keshavan, Ashvini
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Barker, Suzanne
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Jäger, Hans Rolf
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Carletti, Francesco
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Simister, Robert
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Werring, David J
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Spyer, Moira J
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Nastouli, Eleni
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Gauthier, Serge
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Rosa-Neto, Pedro
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Schott, Jonathan M
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Brain communications: Oxford University Press (OUP)3:32632-1297
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Paterson, Ross W
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Mehta, Puja R
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Brown, Rachel L
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Athauda, Dilan
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Leckey, Claire A
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