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Restoring miR-132 e...
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.
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Walgrave, Hannah (author)
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Balusu, Sriram (author)
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Snoeck, Sarah (author)
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Vanden Eynden, Elke (author)
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Craessaerts, Katleen (author)
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Thrupp, Nicky (author)
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Wolfs, Leen (author)
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Horré, Katrien (author)
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Fourne, Yannick (author)
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Ronisz, Alicja (author)
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Silajdžić, Edina (author)
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Penning, Amber (author)
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Tosoni, Giorgia (author)
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Callaerts-Vegh, Zsuzsanna (author)
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D'Hooge, Rudi (author)
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Thal, Dietmar Rudolf (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Thuret, Sandrine (author)
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Fiers, Mark (author)
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Frigerio, Carlo Sala (author)
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De Strooper, Bart (author)
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Salta, Evgenia (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Cell stem cell. - : Elsevier BV. - 1875-9777 .- 1934-5909. ; 28:10
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https://doi.org/10.1...
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Abstract
Subject headings
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- Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally linked to mnemonic and cognitive plasticity in humans and rodents. In Alzheimer's disease (AD), the process of generating new neurons at the hippocampal neurogenic niche is impeded, yet the mechanisms involved are unknown. Here we identify miR-132, one of the most consistently downregulated microRNAs in AD, as a potent regulator of AHN, exerting cell-autonomous proneurogenic effects in adult neural stem cells and their progeny. Using distinct AD mouse models, cultured human primary and established neural stem cells, and human patient material, we demonstrate that AHN is directly affected by AD pathology. miR-132 replacement in adult mouse AD hippocampus restores AHN and relevant memory deficits. Our findings corroborate the significance of AHN in mouse models of AD and reveal the possible therapeutic potential of targeting miR-132 in neurodegeneration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer Disease
- genetics
- Animals
- Disease Models
- Animal
- Hippocampus
- Humans
- Memory Disorders
- genetics
- therapy
- Mice
- MicroRNAs
- genetics
- Neurogenesis
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Walgrave, Hannah
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Balusu, Sriram
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Snoeck, Sarah
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Vanden Eynden, E ...
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Craessaerts, Kat ...
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Thrupp, Nicky
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show more...
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Wolfs, Leen
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Horré, Katrien
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Fourne, Yannick
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Ronisz, Alicja
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Silajdžić, Edina
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Penning, Amber
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Tosoni, Giorgia
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Callaerts-Vegh, ...
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D'Hooge, Rudi
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Thal, Dietmar Ru ...
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Zetterberg, Henr ...
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Thuret, Sandrine
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Fiers, Mark
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Frigerio, Carlo ...
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De Strooper, Bar ...
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Salta, Evgenia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cell stem cell
- By the university
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University of Gothenburg