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Thirty-Day Outcomes...
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Duarte-Salles, Talita
(author)
Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-09-01
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American Academy of Pediatrics (AAP),2021
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/311140
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https://gup.ub.gu.se/publication/311140URI
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https://doi.org/10.1542/peds.2020-042929DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.A total of 242158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2084180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.
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Vizcaya, David
(author)
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Pistillo, Andrea
(author)
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Casajust, Paula
(author)
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Sena, Anthony G
(author)
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Lai, Lana Yin Hui
(author)
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Prats-Uribe, Albert
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Ahmed, Waheed-Ul-Rahman
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Alshammari, Thamir M
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Alghoul, Heba
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Alser, Osaid
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Burn, Edward
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You, Seng Chan
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Areia, Carlos
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Blacketer, Clair
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DuVall, Scott
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Falconer, Thomas
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Fernandez-Bertolin, Sergio
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Fortin, Stephen
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Golozar, Asieh
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Gong, Mengchun
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Tan, Eng Hooi
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Huser, Vojtech
(author)
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Iveli, Pablo
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Morales, Daniel R
(author)
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Nyberg, Fredrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xnybef
(author)
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Posada, Jose D
(author)
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Recalde, Martina
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Roel, Elena
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Schilling, Lisa M
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Shah, Nigam H
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Shah, Karishma
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Suchard, Marc A
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Zhang, Lin
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Zhang, Ying
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Williams, Andrew E
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Reich, Christian G
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Hripcsak, George
(author)
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Rijnbeek, Peter
(author)
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Ryan, Patrick
(author)
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Kostka, Kristin
(author)
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Prieto-Alhambra, Daniel
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
(creator_code:org_t)
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In:Pediatrics: American Academy of Pediatrics (AAP)148:31098-42750031-4005
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Duarte-Salles, T ...
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Vizcaya, David
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Pistillo, Andrea
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Casajust, Paula
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Sena, Anthony G
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Lai, Lana Yin Hu ...
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Prats-Uribe, Alb ...
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Ahmed, Waheed-Ul ...
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Alghoul, Heba
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Alser, Osaid
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Burn, Edward
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You, Seng Chan
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Areia, Carlos
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Blacketer, Clair
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DuVall, Scott
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Falconer, Thomas
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Fernandez-Bertol ...
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Fortin, Stephen
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Golozar, Asieh
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Gong, Mengchun
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Tan, Eng Hooi
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Huser, Vojtech
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Iveli, Pablo
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Morales, Daniel ...
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Nyberg, Fredrik, ...
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Posada, Jose D
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Recalde, Martina
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Roel, Elena
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Schilling, Lisa ...
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Shah, Nigam H
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Shah, Karishma
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Suchard, Marc A
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Zhang, Lin
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Zhang, Ying
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Williams, Andrew ...
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Reich, Christian ...
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Hripcsak, George
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Rijnbeek, Peter
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Ryan, Patrick
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Kostka, Kristin
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Prieto-Alhambra, ...
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