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The protective gene...
The protective gene dose effect of the APOE epsilon 2 allele on gray matter volume in cognitively unimpaired individuals
- Article/chapterEnglish2022
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LIBRIS-ID:oai:gup.ub.gu.se/311821
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https://gup.ub.gu.se/publication/311821URI
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https://doi.org/10.1002/alz.12487DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Introduction: Harboring two copies of the apolipoprotein E (APOE) epsilon 2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. Methods: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired epsilon 2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of epsilon 2 genotypic groups were compared to each other and to the reference group (APOE epsilon 3/epsilon 3). Results: Carrying at least one epsilon 2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE epsilon 2 homozygotes, but not APOE epsilon 2 heterozygotes, showed larger GM volumes in areas related to successful aging. Discussion: In addition to the known resistance against amyloid-beta deposition, the larger GM volumes in key brain regions may confer APOE epsilon 2 homozygotes additional protection against AD-related cognitive decline.
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Ferreira, D.
(author)
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Operto, G.
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Cumplido-Mayoral, I.
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Arenaza-Urquijo, E. M.
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Cacciaglia, R.
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Falcon, C.
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Vilor-Tejedor, N.
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Minguillon, C.
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Groot, C.
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van der Flier, W. M.
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Barkhof, F.
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Scheltens, P.
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Ossenkoppele, R.
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Kern, SilkeGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)(Swepub:gu)xkersi
(author)
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Zettergren, Anna,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)(Swepub:gu)xhakan
(author)
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Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xskooi
(author)
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Hort, J.
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Stomrud, E.
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van Westen, D.
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Hansson, O.
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Molinuevo, J. L.
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Wahlund, L. O.
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Westman, E.
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Gispert, J. D.
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Alzheimers & Dementia: Wiley18:7, s. 1383-13951552-52601552-5279
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Salvado, G.
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Ferreira, D.
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Operto, G.
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Cumplido-Mayoral ...
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Arenaza-Urquijo, ...
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Cacciaglia, R.
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Falcon, C.
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Vilor-Tejedor, N ...
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Minguillon, C.
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Groot, C.
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van der Flier, W ...
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Barkhof, F.
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Scheltens, P.
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Ossenkoppele, R.
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Kern, Silke
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Zettergren, Anna ...
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Skoog, Ingmar, 1 ...
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Hort, J.
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Stomrud, E.
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van Westen, D.
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Hansson, O.
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Molinuevo, J. L.
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Wahlund, L. O.
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Westman, E.
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Gispert, J. D.
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