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Nav1.7 is required ...
Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.
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- Middleton, Steven J (author)
- Univ Oxford, England
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- Perini, Irene, 1983- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Andreas C, Themistocleous (author)
- Univ Oxford, England; Univ Witwatersrand, South Africa
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- Weir, Greg A (author)
- Univ Oxford, England; Univ Glasgow, Scotland
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- McCann, Kirsty (author)
- Univ Oxford, England
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- Barry, Allison M (author)
- Univ Oxford, England
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- Marshall, Andrew (author)
- Univ Liverpool, England
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- Lee, Michael (author)
- Univ Cambridge, England
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- Mayo, Leah M., 1987- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Bohic, Manon (author)
- Aix Marseille Univ, France; Rutgers State Univ, NJ 08854 USA
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- Baskozos, Georgios (author)
- Univ Oxford, England
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- Morrison, India, 1972- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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- Löken, Line Sofie, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Sweden
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- Mcintyre, Sarah, 1981- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Nagi, Saad (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Staud, Roland (author)
- Univ Florida, FL 32610 USA
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- Sehlstedt, Isac, 1989 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Univ Gothenburg, Sweden
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- Johnson, Richard D (author)
- Univ Gothenburg, Sweden; Univ Florida, FL 32610 USA
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- Wessberg, Johan, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,Univ Gothenburg, Sweden
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- Wood, John N (author)
- UCL, England
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- Woods, Christopher G (author)
- Univ Cambridge, England
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- Moqrich, Aziz (author)
- Aix Marseille Univ, France
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- Olausson, Håkan, 1965- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Neurofysiologiska kliniken US
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- Bennett, David L (author)
- Univ Oxford, England
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(creator_code:org_t)
- 2021-12-27
- 2022
- English.
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In: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156 .- 0006-8950. ; 145:10, s. 3637-3653
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Nav1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation is reportedly normal. Using psychophysics (n = 6 CIP participants and n = 86 healthy controls) and facial EMG (n = 3 CIP participants and n = 8 healthy controls) we have found that these patients also have abnormalities in the encoding of affective touch which is mediated by the specialised afferents; C-low threshold mechanoreceptors (C-LTMRs). In the mouse we found that C-LTMRs express high levels of Nav1.7. Genetic loss or selective pharmacological inhibition of Nav1.7 in C-LTMRs resulted in a significant reduction in the total sodium current density, an increased mechanical threshold and reduced sensitivity to non-noxious cooling. The behavioural consequence of loss of Nav1.7 in C-LTMRs in mice was an elevation in the von Frey mechanical threshold and less sensitivity to cooling on a thermal gradient. Nav1.7 is therefore not only essential for normal pain perception but also for normal C-LTMR function, cool sensitivity and affective touch.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- affective touch; C-low threshold mechanoreceptors; congenital insensitivity to pain; Na(v)1; 7
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Middleton, Steve ...
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Perini, Irene, 1 ...
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Andreas C, Themi ...
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Weir, Greg A
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McCann, Kirsty
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Barry, Allison M
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Marshall, Andrew
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Lee, Michael
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Mayo, Leah M., 1 ...
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Bohic, Manon
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Baskozos, Georgi ...
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Morrison, India, ...
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Löken, Line Sofi ...
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Mcintyre, Sarah, ...
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Nagi, Saad
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Staud, Roland
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Sehlstedt, Isac, ...
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Johnson, Richard ...
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Wessberg, Johan, ...
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Wood, John N
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Woods, Christoph ...
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Moqrich, Aziz
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Olausson, Håkan, ...
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Bennett, David L
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Brain : a journa ...
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Brain
- By the university
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University of Gothenburg
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Linköping University