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Development of Tbet...
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers.
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Song, Wenzhi (author)
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Antao, Olivia Q (author)
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Condiff, Emily (author)
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Sanchez, Gina M (author)
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Chernova, Irene (author)
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Zembrzuski, Krzysztof (author)
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Steach, Holly (author)
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Rubtsova, Kira (author)
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- Angeletti, Davide, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Lemenze, Alexander (author)
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Laidlaw, Brian J (author)
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Craft, Joe (author)
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Weinstein, Jason S (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 55:2
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Tbet+CD11c+ B cells arise during type 1 pathogen challenge, aging, and autoimmunity in mice and humans. Here, we examined the developmental requirements of this B cell subset. In acute infection, T follicular helper (Tfh) cells, but not Th1 cells, drove Tbet+CD11c+ B cell generation through proximal delivery of help. Tbet+CD11c+ B cells developed prior to germinal center (GC) formation, exhibiting phenotypic and transcriptional profiles distinct from GC B cells. Fate tracking revealed that most Tbet+CD11c+ B cells developed independently of GC entry and cell-intrinsic Bcl6 expression. Tbet+CD11c+ and GC B cells exhibited minimal repertoire overlap, indicating distinct developmental pathways. As the infection resolved, Tbet+CD11c+ B cells localized to the marginal zone where splenic retention depended on integrins LFA-1 and VLA-4, forming a competitive memory subset that contributed to antibody production and secondary GC seeding upon rechallenge. Therefore, Tbet+CD11c+ B cells comprise a GC-independent memory subset capable of rapid and robust recall responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Immunity
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- By the author/editor
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Song, Wenzhi
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Antao, Olivia Q
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Condiff, Emily
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Sanchez, Gina M
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Chernova, Irene
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Zembrzuski, Krzy ...
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show more...
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Steach, Holly
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Rubtsova, Kira
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Angeletti, David ...
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Lemenze, Alexand ...
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Laidlaw, Brian J
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Craft, Joe
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Weinstein, Jason ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Immunity
- By the university
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University of Gothenburg