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PSD3 downregulation...
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Mancina, Rosellina MargheritaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
(author)
PSD3 downregulation confers protection against fatty liver disease.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-31
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/313448
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https://gup.ub.gu.se/publication/313448URI
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https://doi.org/10.1038/s42255-021-00518-0DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.
Subject headings and genre
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Sasidharan, KavithaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsaska
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Lindblom, Anna
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Wei, Ying
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Ciociola, EsterGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcioce
(author)
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Oveis, JamialahmadiGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
(author)
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Pingitore, Piero,1986Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xpinpi
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Andréasson, Anne-Christine
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Pellegrini, Giovanni
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Baselli, Guido
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Männistö, Ville
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Pihlajamäki, Jussi
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Kärjä, Vesa
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Grimaudo, Stefania
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Marini, Ilaria
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Maggioni, Marco
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Becattini, BarbaraGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbecba
(author)
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Tavaglione, FedericaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtavfe
(author)
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Dix, Carly
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Castaldo, Marie
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Klein, Stephanie
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Perelis, Mark
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Pattou, Francois
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Thuillier, Dorothée
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Raverdy, Violeta
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Dongiovanni, Paola
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Fracanzani, Anna Ludovica
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Stickel, Felix
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Hampe, Jochen
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Buch, Stephan
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Luukkonen, Panu K
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Prati, Daniele
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Yki-Järvinen, Hannele
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Petta, Salvatore
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Xing, Chao
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Schafmayer, Clemens
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Aigner, Elmar
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Datz, Christian
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Lee, Richard G
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Valenti, Luca
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Lindén, Daniel
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Romeo, Stefano,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xroste
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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In:Nature metabolism: Springer Science and Business Media LLC4:1, s. 60-752522-5812
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Nature metabolis ...
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University of Gothenburg