Search: onr:"swepub:oai:gup.ub.gu.se/313462" >
Workflow of Integra...
Workflow of Integrated Resources to Catalyze Network Driven COVID-19 Research
-
Zahoranszky-Kohalmi, G. (author)
-
Siramshetty, V. B. (author)
-
Kumar, P. (author)
-
show more...
-
Gurumurthy, M. (author)
-
Grillo, B. (author)
-
Mathew, B. (author)
-
Metaxatos, D. (author)
-
Backus, M. (author)
-
Mierzwa, T. (author)
-
Simon, R. (author)
-
Grishagin, I. (author)
-
Brovold, L. (author)
-
Mathe, E. A. (author)
-
Hall, M. D. (author)
-
Michael, S. G. (author)
-
Godfrey, A. G. (author)
-
Mestres, J. (author)
-
Jensen, L. J. (author)
-
- Oprea, Tudor I (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
show less...
-
(creator_code:org_t)
- 2022-01-20
- 2022
- English.
-
In: Journal of Chemical Information and Modeling. - : American Chemical Society (ACS). - 1549-9596 .- 1549-960X. ; 62:3, s. 718-729
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one of the strategies that has the potential to deliver therapeutics relatively quickly. The SARS-CoV-2 pandemic has shown that integrating critical data resources to drive drug-repositioning studies, involving host-host, host-pathogen, and drug-target interactions, remains a time-consuming effort that translates to a delay in the development and delivery of a life-saving therapy. Here, we describe a workflow we designed for a semiautomated integration of rapidly emerging data sets that can be generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that integrates 487 host-pathogen, 63 278 host- host protein, and 1221 drug-target interactions. The resultant Neo4j graph database named "Neo4COVID19" is made publicly accessible via a web interface and via API calls based on the Bolt protocol. Details for accessing the database are provided on a landing page (https://neo4covid19.ncats.io/). We believe that our Neo4COVID19 database will be a valuable asset to the research community and will catalyze the discovery of therapeutics to fight COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- sars-cov-2
- diagnosis
- uniprot
- Pharmacology & Pharmacy
- Chemistry
- Computer Science
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Zahoranszky-Koha ...
-
Siramshetty, V. ...
-
Kumar, P.
-
Gurumurthy, M.
-
Grillo, B.
-
Mathew, B.
-
show more...
-
Metaxatos, D.
-
Backus, M.
-
Mierzwa, T.
-
Simon, R.
-
Grishagin, I.
-
Brovold, L.
-
Mathe, E. A.
-
Hall, M. D.
-
Michael, S. G.
-
Godfrey, A. G.
-
Mestres, J.
-
Jensen, L. J.
-
Oprea, Tudor I
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmacology and ...
- Articles in the publication
-
Journal of Chemi ...
- By the university
-
University of Gothenburg