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Obstructive sleep a...
Obstructive sleep apnea and stroke: The mechanisms, the randomized trials, and the road ahead
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- Javaheri, S. (author)
- University of Cincinnati College of Medicine,Ohio State University
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- Peker, Yüksel, 1961 (author)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska Academy,University of Pittsburgh
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- Yaggi, H. K. (author)
- Yale University
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- Bassetti, C. L. A. (author)
- University of Bern
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Sleep Medicine Reviews. - : Elsevier BV. - 1087-0792. ; 61:February
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Abstract
Subject headings
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- When considered separately from cardiovascular disease, stroke is the third leading cause of death in the U.S. and is the leading cause of long-term disability in adults. New approaches that can be offered to the majority of ischemic stroke patients, can be continued throughout post-stroke care, can limit stroke severity, and can complement or even enhance rehabilitation, would transform ischemic stroke recovery. The treatment of obstructive sleep apnea (OSA) in patients with acute ischemic stroke may represent one such approach. This manuscript reviews the epidemiologic studies of the bidirectional association between OSA and stroke, and the mechanisms and molecular signatures of OSA leading to transient ischemic attack and stroke as well as the randomized controlled trials and observational cohort studies examining continuous positive airway treatment efficacy on the impact of stroke outcomes. Finally, the insights these studies provide on future research are also discussed. © 2021 Elsevier Ltd
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Continuous positive airway pressure
- Obstructive sleep apnea
- Randomized controlled trials
- Stroke
- acute ischemic stroke
- adaptive servo ventilation
- apnea hypopnea index
- atrial fibrillation
- brain circulation
- cardioembolic stroke
- central sleep apnea syndrome
- cerebrovascular accident
- endothelial dysfunction
- excessive daytime sleepiness
- human
- hypercapnia
- hypercoagulability
- hypertension
- hypoxemia
- ischemic stroke
- oxidative stress
- oxygen desaturation index
- paradoxical embolism
- patent foramen ovale
- pathophysiology
- prevalence
- randomized controlled trial (topic)
- Review
- sleep disordered breathing
- snoring
- transient ischemic attack
Publication and Content Type
- ref (subject category)
- art (subject category)
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