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Effects of dietary ...
Effects of dietary and exercise treatments on HDL subclasses in lactating women with overweight and obesity: a secondary analysis of a randomised controlled trial
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Ohman, E. A. (author)
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Kirchner, L. (author)
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- Winkvist, Anna, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Bertz, Fredrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Holven, K. B. (author)
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Ulven, S. M. (author)
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- Brekke, Hilde Kristin, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- 2022-01-24
- 2022
- English.
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In: British Journal of Nutrition. - : Cambridge University Press (CUP). - 0007-1145 .- 1475-2662. ; 128:11, s. 2105-2114
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Childbearing decreases HDL-cholesterol, potentially contributing to the increased risk of CVD in parous women. Large HDL particles (HDL-P) are associated with lower risk of CVD. In this secondary analysis of a randomised controlled trial, we investigated the effects of 12-week dietary and exercise treatments on HDL-P subclass concentration, size and apoA1 in lactating women with overweight/obesity. At 10-14 weeks postpartum, 68 women with pre-pregnant BMI 25-35 kg/m(2) were randomised to four groups using 2 x 2 factorial design: (1) dietary treatment for weight loss; (2) exercise treatment; (3) both treatments and (4) no treatment. Lipoprotein subclass profiling by NMR spectroscopy was performed in serum at randomisation and after 3 and 12 months, and the results analysed with two-way ANCOVA. Lipid concentrations decline naturally postpartum. At 3 months (5-6 months postpartum), both diet (P = 0 center dot 003) and exercise (P = 0 center dot 008) reduced small HDL-P concentration. Concurrently, exercise limited the decline in very large HDL-P (P = 0 center dot 002) and the effect was still significant at 12 months (15 months postpartum) (P = 0 center dot 041). At 12 months, diet limited the decline in very large HDL-P (P = 0 center dot 005), large HDL-P (P = 0 center dot 001) and apoA1 (P = 0 center dot 002) as well as HDL size (P = 0 center dot 002). The dietary treatment for weight loss and the exercise treatment both showed effects on HDL-P subclasses in lactating women with overweight and obesity possibly associated with lower CVD risk. The dietary treatment had more effects than the exercise treatment at 12 months, likely associated with a 10 % weight loss.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Dietary treatment
- Diet
- Exercise
- Postpartum
- Weight loss
- HDL
- Overweight
- coronary-heart-disease
- density-lipoprotein cholesterol
- magnetic-resonance metabolomics
- cardiovascular-disease
- weight-loss
- particle-size
- risk-factors
- lipids
- subpopulations
- epidemiology
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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