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Cerebrospinal fluid...
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pascoal, Tharick A. (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Lantero Rodriguez, Juan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Brum, Wagner S. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Mathotaarachchi, S. (author)
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Therriault, J. (author)
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Savard, M. (author)
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Chamoun, M. (author)
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Stoops, E. (author)
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Francois, C. (author)
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Vanmechelen, E. (author)
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Gauthier, S. (author)
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Zimmer, E. R. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Rosa-Neto, P. (author)
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Ebiomedicine. - : Elsevier BV. - 2352-3964. ; 76
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Abstract
Subject headings
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- Background: Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are seen to be increased in preclinical stage of the disease. However, it is unknown if these increases transpire earlier, prior to amyloid-beta (Aβ) positivity as determined by position emission tomography (PET), and if an ordinal sequence of p-tau epitopes occurs at this incipient phase Methods: We measured CSF concentrations of p-tau181, p-tau217 and p-tau231 in 171 participants across the AD continuum who had undergone Aβ ([18F]AZD4694) and tau ([18F]MK6240) position emission tomography (PET) and clinical assessment Findings: All CSF p-tau biomarkers were accurate predictors of cognitive impairment but CSF p-tau217 demonstrated the largest fold-changes in AD patients in comparison to non-AD dementias and cognitively unimpaired individuals. CSF p-tau231 and p-tau217 predicted Aβ and tau to a similar degree but p-tau231 attained abnormal levels first. P-tau231 was sensitive to the earliest changes of Aβ in the medial orbitofrontal, precuneus and posterior cingulate before global Aβ PET positivity was reached Interpretation: We demonstrate that CSF p-tau231 increases early in development of AD pathology and is a principal candidate for detecting incipient Aβ pathology for therapeutic trial application Funding: Canadian Institutes of Health Research (CIHR), Canadian Consortium of Neurodegeneration and Aging, Weston Brain Institute, Brain Canada Foundation, the Fonds de Recherche du Québec. © 2022
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid
- Cerebrospinal fluid
- Phosphorylated tau
- Positron emission tomography
- Preclinical
- amyloid beta protein
- biological marker
- epitope
- flutafuranol
- glycogen synthase kinase
- tau 217
- tau 231
- tau protein
- unclassified drug
- adult
- aged
- aging
- Alzheimer disease
- Article
- cognition
- cognitive defect
- cohort analysis
- computer language
- controlled study
- dementia
- diagnostic accuracy
- diagnostic test accuracy study
- enzyme linked immunosorbent assay
- epitope mapping
- female
- frontotemporal dementia
- human
- image analysis
- male
- middle aged
- neurofibrillary tangle
- pathology
- posterior cingulate
- protein phosphorylation
- quality control
- receiver operating characteristic
- sensitivity and specificity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ashton, Nicholas ...
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Lessa Benedet, A ...
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Pascoal, Tharick ...
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Karikari, Thomas
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Lantero Rodrigue ...
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Brum, Wagner S.
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show more...
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Mathotaarachchi, ...
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Therriault, J.
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Savard, M.
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Chamoun, M.
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Stoops, E.
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Francois, C.
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Vanmechelen, E.
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Gauthier, S.
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Zimmer, E. R.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Rosa-Neto, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Ebiomedicine
- By the university
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University of Gothenburg