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Characterization of...
Characterization of the genetic architecture of infant and early childhood body mass index.
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Helgeland, Øyvind (author)
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Vaudel, Marc (author)
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- Solé Navais, Pol (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Flatley, Christopher (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Juodakis, Julius (author)
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Bacelis, Jonas (author)
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Koløen, Ingvild L (author)
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Knudsen, Gun Peggy (author)
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Johansson, Bente B (author)
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Magnus, Per (author)
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Kjennerud, Ted Reichborn (author)
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Juliusson, Petur B (author)
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Stoltenberg, Camilla (author)
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Holmen, Oddgeir L (author)
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Andreassen, Ole A (author)
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- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Njølstad, Pål R (author)
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Johansson, Stefan (author)
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(creator_code:org_t)
- 2022-03-21
- 2022
- English.
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In: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 4:3, s. 344-358
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Abstract
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- Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index at specific ages, matching different child growth phases, and representing four major trajectory patterns. We perform genome-wide association studies across 12 time points from birth to 8 years in 28,681 children and their parents (27,088 mothers and 26,239 fathers) in the Norwegian Mother, Father and Child Cohort Study. Monogenic obesity genes are overrepresented near identified loci, and several complex association signals near LEPR, GLP1R, PCSK1 and KLF14 point towards a major influence for common variation affecting the leptin-melanocortin system in early life, providing a link to putative treatment strategies. We also demonstrate how different polygenic risk scores transition from birth to adult profiles through early child growth. In conclusion, our results offer a fine-grained characterization of a changing genetic landscape sustaining early childhood growth.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Helgeland, Øyvin ...
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Vaudel, Marc
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Solé Navais, Pol
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Flatley, Christo ...
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Juodakis, Julius
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Bacelis, Jonas
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show more...
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Koløen, Ingvild ...
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Knudsen, Gun Peg ...
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Johansson, Bente ...
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Magnus, Per
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Kjennerud, Ted R ...
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Juliusson, Petur ...
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Stoltenberg, Cam ...
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Holmen, Oddgeir ...
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Andreassen, Ole ...
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Jacobsson, Bo, 1 ...
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Njølstad, Pål R
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Johansson, Stefa ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Nature metabolis ...
- By the university
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University of Gothenburg