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Lipoxins modulate n...
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Kraft, Jamie D.Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
(author)
Lipoxins modulate neutrophil oxidative burst, integrin expression and lymphatic transmigration differentially in human health and atherosclerosis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Hoboken, NJ, United States :John Wiley & Sons,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/314508
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https://gup.ub.gu.se/publication/314508URI
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https://doi.org/10.1096/fj.202101219RRDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183764URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies: Vetenskapsrådet (VR) Swedish Research Council [2016/82]; Svenska Sällskapet for Medicinsk Forskning (SSMF) [S150086]; EC \ H2020 \ H2020 Priority Excellent Science \ H2020 European Research Council (ERC) [804418]; Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)
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Dysregulated chronic inflammation plays a crucial role in the pathophysiology of atherosclerosis and may be a result of impaired resolution. Thus, restoring levels of specialized pro-resolving mediators (SPMs) to promote the resolution of inflammation has been proposed as a therapeutic strategy for patients with atherosclerosis, in addition to standard clinical care. Herein, we evaluated the effects of the SPM lipids, lipoxin A4 (LXA4) and lipoxin B4 (LXB4), on neutrophils isolated from patients with atherosclerosis compared with healthy controls. Patients displayed altered endogenous SPM production, and we demonstrated that lipoxin treatment in whole blood from atherosclerosis patients attenuates neutrophil oxidative burst, a key contributor to atherosclerotic development. We found the opposite effect in neutrophils from healthy controls, indicating a potential mechanism whereby lipoxins aid the endogenous neutrophil function in health but reduce its excessive activation in disease. We also demonstrated that lipoxins attenuated upregulation of the high-affinity conformation of the CD11b/CD18 integrin, which plays a central role in clot activation and atherosclerosis. Finally, LXB4 enhanced lymphatic transmigration of human neutrophils isolated from patients with atherosclerosis. This finding is noteworthy, as impaired lymphatic function is now recognized as an important contributor to atherosclerosis. Although both lipoxins modulated neutrophil function, LXB4 displayed more potent effects than LXA4 in humans. This study highlights the therapeutic potential of lipoxins in atherosclerotic disease and demonstrates that the effect of these SPMs may be specifically tailored to the need of the individual. © 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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Blomgran, Robert,1975-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)robbl96
(author)
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Bergström, Ida,1982-Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)idabe12
(author)
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Soták, MatusGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
(author)
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Clark, MadisonGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden
(author)
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Rani, AlankritaGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden(Swepub:gu)xrania
(author)
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Rohin Rajan, MeenuGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Centre for Molecular and Translational Medicine,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
(author)
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Dalli, J.Queen Mary Univ London, England
(author)
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Nyström, Sofia N.,1971-Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)sofny82
(author)
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Quiding-Järbrink, Marianne,1964Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Univ Gothenburg, Sweden(Swepub:gu)xquima
(author)
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Bromberg, J.Univ Maryland, USA
(author)
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Skoog, PerGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Univ Hosp & Acad, Sweden(Swepub:gu)xskoop
(author)
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Börgeson, EmmaGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden(Swepub:gu)xboemm
(author)
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Göteborgs universitetWallenberg Centre for Molecular and Translational Medicine
(creator_code:org_t)
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In:FASEB JournalHoboken, NJ, United States : John Wiley & Sons36:30892-66381530-6860
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