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Diagnostic Dosimetry
Diagnostic Dosimetry
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- Johansson, Lennart (author)
- Umeå University,Umeå universitet,Radiofysik
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- Andersson, Martin (author)
- University of Gothenburg,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Clinical Sciences, Department of Medical Radiation Sciences,Sahlgrenska Center for Cancer Research (SCCR),Lund University, Department of Medical Radiation Sciences, Malmö, Sweden; Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Sweden,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical Radiation Physics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
- Boca Raton : CRC Press, 2022
- 2022
- English.
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In: Handbook of Nuclear Medicine and Molecular Imaging for Physicists. - Boca Raton : CRC Press. - 9780429489549 ; , s. 33-68
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Abstract
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- Diagnostic nuclear medicine, more recently also named functional molecular imaging, deals with medical procedures performed to help diagnose a variety of diseases. The procedures are based on the use of tracer amounts of radioactive material, where a radionuclide is attached to a ligand with specific affinity to a physiological, metabolic, or receptor-specific process. To balance the benefit of a procedure, the calculation of the mean absorbed dose in organs and tissues for representative groups of patients is one important parameter in the justification of the diagnostic procedure. This also applies to the use of radiopharmaceuticals to volunteers in clinical research. Specific biokinetic models are created to describes the uptake, turn-over and retention in the human body. Together with mathematically describable anatomical models, representing groups of patients, these are used to estimate the mean absorbed dose in organs and tissues. This facilitate the estimations of the quantity effective dose, which is a dose quantity to estimate the risk to later in life develop a radiation-induced cancer for a group of reference patients. The chapter describes methods for diagnostic internal dosimetry, assessment of biokinetic data for individual patients/volunteers as well as construction of biokinetic and dosimetric models for representative groups of patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publication and Content Type
- ref (subject category)
- kap (subject category)
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