onr:"swepub:oai:gup.ub.gu.se/314686"
Search: onr:"swepub:oai:gup.ub.gu.se/314686" > Sex-specific lesion...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08588naa a2201165 4500 | |
| 001 | oai:gup.ub.gu.se/314686 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:03c92117-7408-45fc-b465-5105e0d26e2c | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3146862 URI |
| 024 | 7 | a https://doi.org/10.1093/braincomms/fcac0202 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/03c92117-7408-45fc-b465-5105e0d26e2c2 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bonkhoff, A. K.u Harvard Medical School4 aut |
| 245 | 1 0 | a Sex-specific lesion pattern of functional outcomes after stroke |
| 264 | c 2022-02-02 | |
| 264 | 1 | b Oxford University Press (OUP),c 2022 |
| 520 | a Relying on neuroimaging and clinical data of 822 acute stroke patients, Bonkhoff et al. report substantially more detrimental effects of lesions in left-hemispheric posterior circulation regions on functional outcomes in women compared to men. These findings may motivate a sex-specific clinical stroke management to improve outcomes in the longer term. Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men - women) = -0.295 (90% highest posterior density interval = -0.556 to -0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a acute ischaemic stroke | |
| 653 | a functional outcomes | |
| 653 | a sex differences | |
| 653 | a lesion | |
| 653 | a patterns | |
| 653 | a Bayesian hierarchical modelling | |
| 653 | a human cerebral-cortex | |
| 653 | a area | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Bretzner, M.4 aut |
| 700 | 1 | a Söderholm, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ms8 |
| 700 | 1 | a Schirmer, M. D.4 aut |
| 700 | 1 | a Cohen, A.4 aut |
| 700 | 1 | a Regenhardt, R. W.4 aut |
| 700 | 1 | a Donahue, K. L.4 aut |
| 700 | 1 | a Nardin, M. J.4 aut |
| 700 | 1 | a Dalca, A. V.4 aut |
| 700 | 1 | a Giese, A. K.4 aut |
| 700 | 1 | a Etherton, M. R.4 aut |
| 700 | 1 | a Hancock, B. L.4 aut |
| 700 | 1 | a Stanne, Tara M,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xmcdta |
| 700 | 1 | a McIntosh, E. C.4 aut |
| 700 | 1 | a Attia, J.4 aut |
| 700 | 1 | a Benavente, O. R.4 aut |
| 700 | 1 | a Bevan, S.4 aut |
| 700 | 1 | a Wasselius, Johanu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)oft-jws |
| 700 | 1 | a Donatti, A.4 aut |
| 700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjerch |
| 700 | 1 | a Heitsch, L.4 aut |
| 700 | 1 | a Holmegaard, Lukasu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xhollu |
| 700 | 1 | a Jood, Katarina,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjooka |
| 700 | 1 | a Jimenez-Conde, J.4 aut |
| 700 | 1 | a Kittner, S. J.4 aut |
| 700 | 1 | a Lemmens, R.4 aut |
| 700 | 1 | a Levi, C. R.4 aut |
| 700 | 1 | a McDonough, C. W.4 aut |
| 700 | 1 | a Meschia, J. F.4 aut |
| 700 | 1 | a Phuah, C. L.4 aut |
| 700 | 1 | a Rolfs, A.4 aut |
| 700 | 1 | a Ropele, S.4 aut |
| 700 | 1 | a Rosand, J.4 aut |
| 700 | 1 | a Roquer, J.4 aut |
| 700 | 1 | a Rundek, T.4 aut |
| 700 | 1 | a Sacco, R. L.4 aut |
| 700 | 1 | a Schmidt, R.u Harvard Medical School4 aut |
| 700 | 1 | a Sharma, P.4 aut |
| 700 | 1 | a Slowik, A.4 aut |
| 700 | 1 | a Soderholm, M.4 aut |
| 700 | 1 | a Sousa, A.4 aut |
| 700 | 1 | a Stanne, Tara M,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xmcdta |
| 700 | 1 | a Strbian, D.4 aut |
| 700 | 1 | a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt |
| 700 | 1 | a Thijs, V.4 aut |
| 700 | 1 | a Vagal, A.4 aut |
| 700 | 1 | a Wasselius, J.4 aut |
| 700 | 1 | a Woo, D.4 aut |
| 700 | 1 | a Zand, R.4 aut |
| 700 | 1 | a McArdle, P. F.4 aut |
| 700 | 1 | a Worrall, B. B.4 aut |
| 700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjerch |
| 700 | 1 | a Lindgren, Arne G.u Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)neur-ali |
| 700 | 1 | a Maguire, J.4 aut |
| 700 | 1 | a Fox, M. D.4 aut |
| 700 | 1 | a Bzdok, D.4 aut |
| 700 | 1 | a Wu, O. N.4 aut |
| 700 | 1 | a Rost, N. S.4 aut |
| 710 | 2 | a Harvard Medical Schoolb Kardiovaskulär forskning - epidemiologi4 org |
| 710 | 2 | a et al. |
| 773 | 0 | t Brain Communicationsd : Oxford University Press (OUP)g 4:2q 4:2x 2632-1297 |
| 856 | 4 | u https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcac020/42369283/fcac020.pdf |
| 856 | 4 | u http://dx.doi.org/10.1093/braincomms/fcac020x freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/314686 |
| 856 | 4 8 | u https://doi.org/10.1093/braincomms/fcac020 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/03c92117-7408-45fc-b465-5105e0d26e2c |
Find in a library
- Brain Communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bonkhoff, A. K.
- Bretzner, M.
- Söderholm, Marti ...
- Schirmer, M. D.
- Cohen, A.
- Regenhardt, R. W ...
- show more...
- Donahue, K. L.
- Nardin, M. J.
- Dalca, A. V.
- Giese, A. K.
- Etherton, M. R.
- Hancock, B. L.
- Stanne, Tara M, ...
- McIntosh, E. C.
- Attia, J.
- Benavente, O. R.
- Bevan, S.
- Wasselius, Johan
- Donatti, A.
- Jern, Christina, ...
- Heitsch, L.
- Holmegaard, Luka ...
- Jood, Katarina, ...
- Jimenez-Conde, J ...
- Kittner, S. J.
- Lemmens, R.
- Levi, C. R.
- McDonough, C. W.
- Meschia, J. F.
- Phuah, C. L.
- Rolfs, A.
- Ropele, S.
- Rosand, J.
- Roquer, J.
- Rundek, T.
- Sacco, R. L.
- Schmidt, R.
- Sharma, P.
- Slowik, A.
- Soderholm, M.
- Sousa, A.
- Strbian, D.
- Tatlisumak, Turg ...
- Thijs, V.
- Vagal, A.
- Wasselius, J.
- Woo, D.
- Zand, R.
- McArdle, P. F.
- Worrall, B. B.
- Lindgren, Arne G ...
- Maguire, J.
- Fox, M. D.
- Bzdok, D.
- Wu, O. N.
- Rost, N. S.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
- Articles in the publication
- Brain Communicat ...
- By the university
- University of Gothenburg
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
