Search: onr:"swepub:oai:gup.ub.gu.se/314844" >
Cerebrospinal fluid...
-
Eratne, D.University of Melbourne,Royal Melbourne Hospital,The Florey Institute of Neuroscience and Mental Health
(author)
Cerebrospinal fluid neurofilament light chain differentiates primary psychiatric disorders from rapidly progressive, Alzheimer's disease and frontotemporal disorders in clinical settings
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/314844
-
https://gup.ub.gu.se/publication/314844URI
-
https://doi.org/10.1002/alz.12549DOI
-
https://lup.lub.lu.se/record/a48825c4-ab3d-477b-b8dd-ae8b32a7d7c9URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Introduction Many patients with cognitive and neuropsychiatric symptoms face diagnostic delay and misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) and total-tau (t-tau) could assist in the clinical scenario of differentiating neurodegenerative (ND) from psychiatric disorders (PSY), and rapidly progressive disorders. Methods Biomarkers were examined in patients from specialist services (ND and PSY) and a national Creutzfeldt-Jakob registry (Creutzfeldt-Jakob disease [CJD] and rapidly progressive dementias/atypically rapid variants of common ND, RapidND). Results A total of 498 participants were included: 197 ND, 67 PSY, 161 CJD, 48 RapidND, and 20 controls. NfL was elevated in ND compared to PSY and controls, with highest levels in CJD and RapidND. NfL distinguished ND from PSY with 95%/78% positive/negative predictive value, 92%/87% sensitivity/specificity, 91% accuracy. NfL outperformed t-tau in most real-life clinical diagnostic dilemma scenarios, except distinguishing CJD from RapidND. Discussion We demonstrated strong generalizable evidence for the diagnostic utility of CSF NfL in differentiating ND from psychiatric disorders, with high accuracy.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Loi, S. M.Royal Melbourne Hospital,University of Melbourne,The Florey Institute of Neuroscience and Mental Health
(author)
-
Li, Q. X.The Florey Institute of Neuroscience and Mental Health
(author)
-
Stehmann, C.University of Melbourne,The Florey Institute of Neuroscience and Mental Health
(author)
-
Malpas, C. B.Royal Melbourne Hospital
(author)
-
Santillo, AlexanderLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ast
(author)
-
Janelidze, ShorenaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)nkir-sje
(author)
-
Cadwallader, C.
(author)
-
Walia, N.Royal Melbourne Hospital
(author)
-
Ney, B.St. Vincent's Hospital, Melbourne,The Florey Institute of Neuroscience and Mental Health
(author)
-
Lewis, V.The Florey Institute of Neuroscience and Mental Health,University of Melbourne
(author)
-
Senesi, M.
(author)
-
Fowler, C.The Florey Institute of Neuroscience and Mental Health
(author)
-
McGlade, A.The Florey Institute of Neuroscience and Mental Health,Royal Melbourne Hospital,University of Melbourne
(author)
-
Varghese, S.The Florey Institute of Neuroscience and Mental Health
(author)
-
Ravanfar, P.University of Melbourne,Royal Melbourne Hospital
(author)
-
Kelso, W.Royal Melbourne Hospital
(author)
-
Farrand, S.University of Melbourne,Royal Melbourne Hospital
(author)
-
Keem, M.Royal Melbourne Hospital
(author)
-
Kang, M.Royal Melbourne Hospital
(author)
-
Goh, A. M. Y.
(author)
-
Dhiman, K.Deakin University,Edith Cowan University
(author)
-
Gupta, V.Deakin University,Edith Cowan University
(author)
-
Watson, R.Walter and Eliza Hall Institute of Medical Research
(author)
-
Yassi, N.Walter and Eliza Hall Institute of Medical Research,University of Melbourne
(author)
-
Kaylor-Hughes, C.University of Melbourne
(author)
-
Kanaan, R.University of Melbourne
(author)
-
Perucca, P.University of Melbourne,Monash University
(author)
-
Dobson, H.Alfred Health,Royal Melbourne Hospital
(author)
-
Vivash, L.Monash University
(author)
-
Ali, R.Monash University
(author)
-
O'Brien, T. J.Monash University
(author)
-
Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,University College London,UK Dementia Research Institute,Sahlgrenska University Hospital(Swepub:lu)med-hiz
(author)
-
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-kbw
(author)
-
Walterfang, M.Royal Melbourne Hospital,University of Melbourne,The Florey Institute of Neuroscience and Mental Health
(author)
-
Masters, C. L.The Florey Institute of Neuroscience and Mental Health
(author)
-
Berkovic, S. F.
(author)
-
Collins, S.The Florey Institute of Neuroscience and Mental Health,University of Melbourne
(author)
-
Velakoulis, D.University of Melbourne,Royal Melbourne Hospital
(author)
-
Mi, N. D. Study Grp
(author)
-
University of MelbourneRoyal Melbourne Hospital
(creator_code:org_t)
-
MiND Study Group
Related titles
-
In:Alzheimers & Dementia: Wiley18:11, s. 2218-22331552-52601552-5279
Internet link
Find in a library
To the university's database
- By the author/editor
-
Eratne, D.
-
Loi, S. M.
-
Li, Q. X.
-
Stehmann, C.
-
Malpas, C. B.
-
Santillo, Alexan ...
-
show more...
-
Janelidze, Shore ...
-
Cadwallader, C.
-
Walia, N.
-
Ney, B.
-
Lewis, V.
-
Senesi, M.
-
Fowler, C.
-
McGlade, A.
-
Varghese, S.
-
Ravanfar, P.
-
Kelso, W.
-
Farrand, S.
-
Keem, M.
-
Kang, M.
-
Goh, A. M. Y.
-
Dhiman, K.
-
Gupta, V.
-
Watson, R.
-
Yassi, N.
-
Kaylor-Hughes, C ...
-
Kanaan, R.
-
Perucca, P.
-
Dobson, H.
-
Vivash, L.
-
Ali, R.
-
O'Brien, T. J.
-
Hansson, Oskar
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Walterfang, M.
-
Masters, C. L.
-
Berkovic, S. F.
-
Collins, S.
-
Velakoulis, D.
-
Mi, N. D. Study ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Alzheimers & Dem ...
- By the university
-
University of Gothenburg
-
Lund University