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Low-Dose Aspirin fo...
Low-Dose Aspirin for Preventing Birth of a Small-For-Gestational Age Neonate in a Subsequent Pregnancy.
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- Hastie, Roxanne (author)
- Uppsala universitet,Klinisk obstetrik,Roxanne Hastie, MEpi, PhD, Department of Obstetrics and Gynecology, University of Melbourne, Mercy Hospital for Women, Victoria, Australia
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Tong, Stephen (author)
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- Wikström, Anna-Karin, 1965- (author)
- Uppsala universitet,Klinisk obstetrik
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Walker, Susan P (author)
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Lindquist, Anthea (author)
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Cluver, Catherine A (author)
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- Kupka, Ellen (author)
- Uppsala universitet,Centrum för klinisk forskning Dalarna
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- Bergman, Lina, 1982 (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Centrum för klinisk forskning Dalarna,Klinisk obstetrik
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- Hesselman, Susanne, 1973- (author)
- Uppsala universitet,Klinisk obstetrik,Centrum för klinisk forskning Dalarna
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- English.
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In: Obstetrics and gynecology. - : Ovid Technologies (Wolters Kluwer Health). - 1873-233X .- 0029-7844. ; 139:4, s. 529-535
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Abstract
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- To estimate whether low-dose aspirin use is associated with an altered risk of delivering a small-for-gestational age (SGA) neonate among women with a history of having an SGA neonate in a prior pregnancy.We performed a Swedish register-based cohort study including women in their second pregnancy who had a history of having an SGA neonate (birth weight less than the 10th percentile). The association between use of low-dose aspirin in subsequent pregnancy and birth of an SGA neonate or a severely SGA neonate (birth weight less than the third percentile) were estimated using inverse propensity-weighted estimation, accounting for potential confounders.Among 8,416 women who gave birth to an SGA neonate in their first pregnancy, 801 (9.5%) used low-dose aspirin during their second pregnancy. The incidence of SGA neonates was similar among women using low-dose aspirin (21.7%) and those who did not use aspirin (20.7%). Low-dose aspirin use in pregnancy was not associated with an altered risk of having an SGA neonate (adjusted relative risk [aRR] 0.86, 95% CI 0.67-1.10) or a severely SGA neonate (aRR 0.98, 95% CI 0.71-1.34). Given the strong association between preeclampsia and SGA, we performed subgroup analyses based on preeclampsia status. Among women who had an SGA neonate and co-existing preeclampsia in their first pregnancy, low-dose aspirin was not associated with an altered risk of having an SGA (aRR 0.83, 95% CI 0.63-1.10) or severely SGA (aRR 1.02, 95% CI 0.73-1.44) neonate. Additionally, no association was seen among women who developed preeclampsia in their second pregnancy.Among women with a history of having an SGA neonate, low-dose aspirin was not associated with a decreased risk of having an SGA or severely SGA neonate in subsequent pregnancy. These findings suggest that low-dose aspirin should not be used to prevent recurrent SGA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hastie, Roxanne
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Tong, Stephen
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Wikström, Anna-K ...
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Walker, Susan P
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Lindquist, Anthe ...
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Cluver, Catherin ...
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show more...
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Kupka, Ellen
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Bergman, Lina, 1 ...
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Hesselman, Susan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Obstetrics and g ...
- By the university
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University of Gothenburg
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Uppsala University