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High-resolution ex ...
High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D
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- Kruger, D. (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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- Galli, Silvia (author)
- Malmö University,Malmö universitet,Odontologiska fakulteten (OD)
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- Zeller-Plumhoff, Berit (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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- Wieland, D. C. F. (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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- Peruzzi, Niccolò (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wiese, B. (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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- Heuser, P. (author)
- Deutsches Elektronen-Synchrotron (DESY), Germany,German Electron Synchrotron (DESY)
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- Moosmann, J. (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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- Wennerberg, Ann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2,University of Gothenburg
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- Willumeit-Romer, R. (author)
- Helmholtz-Zentrum Hereon, Germany,Helmholtz-Zentrum Geesthacht
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Bioactive Materials. - : Elsevier BV. - 2452-199X. ; 13, s. 37-52
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Abstract
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- Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration. Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to in vitro data obtained from the same material and shape. The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK. The results suggest that both Mg-xGd alloys are suitable as materials for bone implants.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Magnesium alloys
- Biodegradable implant
- Micro-computed tomography
- degradation rate
- Degradation homogeneity
- Ex vivo imaging
- Ex vivo
- histology
- Histology vs. tomography
- in-vivo
- magnesium alloys
- rare-earth
- bone
- vitro
- accumulation
- biomaterials
- gadolinium
- corrosion
- strength
- Engineering
- Materials Science
- Biomedical Engineering
- Hälsa och samhälle
- Ex vivo histology
- Micro-computed tomography degradation rate
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kruger, D.
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Galli, Silvia
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Zeller-Plumhoff, ...
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Wieland, D. C. F ...
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Peruzzi, Niccolò
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Wiese, B.
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show more...
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Heuser, P.
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Moosmann, J.
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Wennerberg, Ann, ...
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Willumeit-Romer, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Bioactive Materi ...
- By the university
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University of Gothenburg
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Malmö University
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Lund University