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Lack of direct association between oral mucosal lesions and SARS-CoV-2 in a cohort of patients hospitalised with COVID-19

Schwab, G. (author)
Palmieri, M. (author)
Zerbinati, R. M. (author)
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Sarmento, D. J. S. (author)
Reis, T. (author)
Ortega, K. L. (author)
Kano, I. T. (author)
Caixeta, R. A. V. (author)
Hasséus, Bengt, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1
Sapkota, D. (author)
Junges, R. (author)
Giannecchini, S. (author)
Costa, A. L. F. (author)
Jales, Smcp (author)
Lindoso, J. A. L. (author)
Gallo, C. B. (author)
Braz-Silva, P. H. (author)
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 (creator_code:org_t)
2022-03-10
2022
English.
In: Journal of Oral Microbiology. - : Informa UK Limited. - 2000-2297. ; 14:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background COVID-19 is a disease affecting various human organs and systems, in which the virus seeks to interact with angiotensin-converting enzyme 2 receptors. These receptors are present in the oral cavity, but the direct relationship between such an interaction and possible oral manifestations of COVID-19 is still unclear. Aim The present study evaluated oral manifestations in a cohort of COVID-19 patients during the period of hospitalisation. Methods In total, 154 patients presenting moderate-to-severe forms of COVID-19 had their oral mucosa examined twice a week until the final outcome, either discharge or death. The oral alterations observed in the patients were grouped into Group 1 (pre-existing conditions and opportunistic oral lesions) and Group 2 (oral mucosal changes related to hospitalization). Results Oral lesions found in the patients of Group 1 are not suggestive of SARS-CoV-2 infection as they are mainly caused by opportunistic infections. On the other hand, oral alterations found in the patients of Group 2 were statistically (P < 0.001) related to intubation and longer period of hospitalisation. Conclusion It is unlikely that ulcerative lesions in the oral cavity are a direct manifestation of SARS-CoV-2 or a marker of COVID-19 progression.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

Oral ulcer
opportunistic infections
COVID-19
HSV-1
SARS-CoV-2
simplex-virus infection
ace2
Microbiology

Publication and Content Type

ref (subject category)
art (subject category)

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