Lack of direct association between oral mucosal lesions and SARS-CoV-2 in a cohort of patients hospitalised with COVID-19

Background COVID-19 is a disease affecting various human organs and systems, in which the virus seeks to interact with angiotensin-converting enzyme 2 receptors. These receptors are present in the oral cavity, but the direct relationship between such an interaction and possible oral manifestations of COVID-19 is still unclear. Aim The present study evaluated oral manifestations in a cohort of COVID-19 patients during the period of hospitalisation. Methods In total, 154 patients presenting moderate-to-severe forms of COVID-19 had their oral mucosa examined twice a week until the final outcome, either discharge or death. The oral alterations observed in the patients were grouped into Group 1 (pre-existing conditions and opportunistic oral lesions) and Group 2 (oral mucosal changes related to hospitalization). Results Oral lesions found in the patients of Group 1 are not suggestive of SARS-CoV-2 infection as they are mainly caused by opportunistic infections. On the other hand, oral alterations found in the patients of Group 2 were statistically (P < 0.001) related to intubation and longer period of hospitalisation. Conclusion It is unlikely that ulcerative lesions in the oral cavity are a direct manifestation of SARS-CoV-2 or a marker of COVID-19 progression.

Palmieri, M. (author)
Zerbinati, R. M. (author)
Sarmento, D. J. S. (author)
Reis, T. (author)
Ortega, K. L. (author)
Kano, I. T. (author)
Caixeta, R. A. V. (author)
Hasséus, Bengt,1955Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 1,Institute of Odontology, Section 1(Swepub:gu)xhasbe (author)
Sapkota, D. (author)
Junges, R. (author)
Giannecchini, S. (author)
Costa, A. L. F. (author)
Jales, Smcp (author)
Lindoso, J. A. L. (author)
Gallo, C. B. (author)
Braz-Silva, P. H. (author)
Göteborgs universitetInstitutionen för odontologi, sektion 1 (creator_code:org_t)

By the author/editor: Schwab, G.; Palmieri, M.; Zerbinati, R. M.; Sarmento, D. J. ...; Reis, T.; Ortega, K. L.; show more...; Kano, I. T.; Caixeta, R. A. V ...; Hasséus, Bengt, ...; Sapkota, D.; Junges, R.; Giannecchini, S.; Costa, A. L. F.; Jales, Smcp; Lindoso, J. A. L ...; Gallo, C. B.; Braz-Silva, P. H ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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