Verbal memory decline and adverse effects on cognition in adult patients with pharmacoresistant partial epilepsy: A longitudinal controlled study of 36 patients

Andersson-Roswall, L (author)

Engman, Elisabeth, 1942 (author): Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences

Samuelsson, Hans, 1955 (author): Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology

Sjöberg-Larsson, C. (author)

Malmgren, Kristina, 1952 (author): Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för kliniska nervsjukdomar,Institute of Clinical Neurosciences, Section of Neurological Diseases

(creator_code:org_t)

Abstract Subject headings

The aim of this study was to delineate possible longitudinal cognitive changes in adult patients with a long history of pharmacoresistant partial epilepsy. Thirty-six patients and thirty healthy controls were investigated at baseline. A reassessment was conducted, with median test intervals of 4.8 years for the patients and 3.1 years for controls. A standardized battery was used for assessment of general cognitive level and memory. At baseline, patients performed at a significantly lower level on general cognition, immediate recall of pairs of associated words, and retention of learned words and visuospatial stimuli, compared with controls. Analyses of change over time in the patients disclosed significant verbal memory decline in retention of pairs of associated words. Group comparisons of change over time revealed adverse effects in the performance aspect of general cognition on the patients. Also, group comparisons indicated impaired performance across time for the patients in retention of pairs of associated words and retention of visuospatial stimuli. The adverse effect on memory and general cognition in this patient group over the period was clear-cut when compared with the longitudinal changes in an adequate control group.

By the author/editor: Andersson-Roswal ...; Engman, Elisabet ...; Samuelsson, Hans ...; Sjöberg-Larsson, ...; Malmgren, Kristi ...

About the subject

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