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The Effect of Lithi...
The Effect of Lithium on the Budding Yeast Saccharomyces cerevisiae upon Stress Adaptation
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- Reith, Patrick Philipp, 1991 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Braam, Svenja, 1989 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Welkenhuysen, Niek, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Lecinski, S. (author)
- University of York
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- Shepherd, J. (author)
- University of York
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- MacDonald, C. (author)
- University of York
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- Cvijovic, Marija, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
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Hohmann, S. (author)
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- Shashkova, Sviatlana, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Cvijovic, Marija, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences
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(creator_code:org_t)
- 2022-03-09
- 2022
- English.
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In: Microorganisms. - : MDPI AG. - 2076-2607. ; 10:3
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Abstract
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- Lithium salts are used in the treatment of mood disorders, cancer, and Alzheimer's disease. It has been shown to prolong life span in several phyla; however, not yet in budding yeast. In our study, we investigate the influence of lithium on yeast cells' viability by characterizing protein aggregate formation, cell volume, and molecular crowding in the context of stress adaptation. While our data suggest a concentration-dependent growth inhibition caused by LiCl, we show an extended long-term survival rate as an effect of lithium addition upon glucose deprivation. We show that caloric restriction mitigates the negative impact of LiCl on cellular survival. Therefore, we suggest that lithium could affect glucose metabolism upon caloric restriction, which could explain the extended long-term survival observed in our study. We find furthermore that lithium chloride did not affect an immediate salt-induced Hsp104-dependent aggregate formation but cellular adaptation to H2O2 and acute glucose starvation. We presume that different salt types and concentrations interfere with effective Hsp104 recruitment or its ATP-dependent disaggregase activity as a response to salt stress. This work provides novel details of Li+ effect on live eukaryotic cells which may also be applicable in further research on the treatment of cancer, Alzheimer's, or other age-related diseases in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- lithium
- osmotic stress
- macromolecular crowding
- protein aggregation
- long-term survival
- yeast
- ionic-strength
- life-span
- amyloid formation
- heat-shock
- phosphoglucomutase
- restriction
- inhibition
- tolerance
- autophagy
- disease
- Microbiology
- Lithium
Publication and Content Type
- ref (subject category)
- art (subject category)
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Reith, Patrick P ...
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Braam, Svenja, 1 ...
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Welkenhuysen, Ni ...
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Lecinski, S.
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Shepherd, J.
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MacDonald, C.
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show more...
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Cvijovic, Marija ...
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Hohmann, S.
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Shashkova, Sviat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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MEDICAL AND HEAL ...
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Microorganisms
- By the university
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University of Gothenburg
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Chalmers University of Technology