Search: onr:"swepub:oai:gup.ub.gu.se/315353" > Development and Val...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05103naa a2200529 4500 | |
001 | oai:gup.ub.gu.se/315353 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3153532 URI |
024 | 7 | a https://doi.org/10.1016/j.cgh.2022.03.0442 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tavaglione, Federicau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xtavfe |
245 | 1 0 | a Development and Validation of a Score for Fibrotic Non-Alcoholic Steatohepatitis. |
264 | 1 | b Elsevier BV,c 2023 |
520 | a Non-invasive assessment of histological features of non-alcoholic fatty liver disease (NAFLD) has been an intensive research area over the last decade. Herein, we aimed to develop a simple non-invasive score using routine laboratory tests to identify, among individuals at high risk for NAFLD, those with fibrotic non-alcoholic steatohepatitis (NASH) defined as NASH, NAFLD activity score (NAS) ≥4, and fibrosis stage ≥2.The derivation cohort included 264 morbidly obese individuals undergoing intraoperative liver biopsy in Rome, Italy. The best predictive model was developed and internally validated using a bootstrapping stepwise logistic regression analysis (2000 bootstrap samples). Performance was estimated by the area under the receiver operating characteristic curve (AUROC). External validation was assessed in three independent European cohorts (Finland, n=370; Italy n=947; England n=5,368) of individuals at high risk for NAFLD.The final predictive model, designated as Fibrotic NASH Index (FNI), combined aspartate aminotransferase (AST), high-density lipoprotein (HDL) cholesterol, and hemoglobin A1c (HbA1c). The performance of FNI for fibrotic NASH was satisfactory in both derivation and external validation cohorts (AUROCs 0.78 and 0.80-0.95, respectively). In the derivation cohort, rule-out and rule-in cut-offs were 0.10 for sensitivity ≥0.89 (negative predictive value [NPV] 0.93) and 0.33 for specificity ≥0.90 (positive predictive value [PPV] 0.57), respectively. In the external validation cohorts, sensitivity ranged from 0.87 to 1 (NPV 0.99-1) and specificity from 0.73 to 0.94 (PPV 0.12-0.49) for rule-out and rule-in cut-off, respectively.FNI is an accurate, simple, and affordable non-invasive score which can be used in primary healthcare to screen for fibrotic NASH individuals with dysmetabolism. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Oveis, Jamialahmadiu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
700 | 1 | a De Vincentis, Antonio4 aut |
700 | 1 | a Qadri, Sami4 aut |
700 | 1 | a Mowlaei, Mohammad Erfan4 aut |
700 | 1 | a Mancina, Rosellina Margheritau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmanro |
700 | 1 | a Ciociola, Esteru Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xcioce |
700 | 1 | a Carotti, Simone4 aut |
700 | 1 | a Perrone, Giuseppe4 aut |
700 | 1 | a Bruni, Vincenzo4 aut |
700 | 1 | a Gallo, Ida Francesca4 aut |
700 | 1 | a Tuccinardi, Dario4 aut |
700 | 1 | a Bianco, Cristiana4 aut |
700 | 1 | a Prati, Daniele4 aut |
700 | 1 | a Manfrini, Silvia4 aut |
700 | 1 | a Pozzilli, Paolo4 aut |
700 | 1 | a Picardi, Antonio4 aut |
700 | 1 | a Caricato, Marco4 aut |
700 | 1 | a Yki-Järvinen, Hannele4 aut |
700 | 1 | a Valenti, Luca4 aut |
700 | 1 | a Vespasiani-Gentilucci, Umberto4 aut |
700 | 1 | a Romeo, Stefano,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xroste |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Associationd : Elsevier BVg 21:6, s. 1523-1532q 21:6<1523-1532x 1542-7714 |
773 | 0 | t Clinical Gastroenterology and Hepatologyd : Elsevier BVg 21:6, s. 1523-1532q 21:6<1523-1532x 1542-3565 |
856 | 4 8 | u https://gup.ub.gu.se/publication/315353 |
856 | 4 8 | u https://doi.org/10.1016/j.cgh.2022.03.044 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view