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Combined electroche...
Combined electrochemistry and mass spectrometry imaging to interrogate the mechanism of action of modafinil, a cognition-enhancing drug, at the cellular and sub-cellular level
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- Ranjbari, Elias (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Philipsen, Mai H., 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Wang, Zhaoying (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Ewing, Andrew G, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
- 2021-07-02
- 2021
- English.
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In: QRB Discovery. - : Cambridge University Press (CUP). - 2633-2892. ; 2
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Abstract
Subject headings
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- (A) Microscope view during the intracellular vesicle impact electrochemical cytometry experiment (scale bar = 20 μm). (B) Normalised frequency histogram for the number of molecules stored in vesicles in control (blue) and modafinil-Treated cells (red). The distribution fits are shown for control cells with a dashed line and modafinil-Treated cells with a solid line. (C) Average of the number of molecules stored per vesicle in PC12 cells treated without (control) or with 10 μM modafinil. Number of analysed cells: control cells (15 cells) and modafinil-Treated cells (18 cells). The results were compared by a two-Tailed Mann-Whitney rank-sum test,*p < 0.05, p < 0.01 and***p < 0.001. ©
Subject headings
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
Keyword
- Cognition-enhancing drug
- intracellular vesicle impact electrochemical cytometry
- modafinil
- single-cell amperometry
- time-of-flight secondary ion mass spectrometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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