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Plasma Amyloid and ...
Plasma Amyloid and in vivo Brain Amyloid in Late Middle-Aged Hispanics.
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Rippon, Brady (author)
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Palta, Priya (author)
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Tahmi, Mouna (author)
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Sherwood, Greysi (author)
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Soto, Luisa (author)
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Cespedes, Sandino (author)
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Mesen, Yanette (author)
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He, Hengda (author)
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Laing, Krystal (author)
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Moreno, Herman (author)
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Teresi, Jeanne (author)
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Razlighi, Qolamreza (author)
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Brickman, Adam M (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Luchsinger, José A (author)
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(creator_code:org_t)
- 2022
- 2022
- English.
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In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 87:3, s. 1229-1238
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Abstract
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- Determining amyloid positivity is possible with cerebrospinal fluid and brain imaging of amyloid, but these methods are invasive and expensive.To relate plasma amyloid-β (Aβ), measured using Single-molecule array (Simoatrademark) assays, to in vivo brain Aβ, measured using positron emission tomography (PET), examine the accuracy of plasma Aβ to predict brain Aβ positivity, and the relation of APOE ɛ4 with plasma Aβ.We performed a cross-sectional analysis in a cohort of 345 late middle-aged Hispanic men and women (age 64 years, 72% women). Our primary plasma variable was Aβ 42/Aβ 40 ratio measured with Simoa. Brain Aβ burden was measured as global SUVR with 18F-Florbetaben PET examined continuously and categorically.Plasma Aβ 42/Aβ 40 ratio was inversely associated with global Aβ SUVR (β=-0.13, 95% Confidence Interval (CI): -0.23, -0.03; p=0.013) and Aβ positivity (Odds Ratio: 0.59, 95% CI: 0.38, 0.91; p=0.016), independent of demographics and APOE ɛ4. ROC curves (AUC=0.73, 95% CI: 0.64, 0.82; p< 0.0001) showed that the optimal threshold for plasma Aβ 42/Aβ 40 ratio in relation to brain Aβ positivity was 0.060 with a sensitivity of 82.4% and specificity of 62.8% . APOE ɛ4 carriers had lower Aβ 42/Aβ 40 ratio and a higher Aβ positivity determined with the Aβ 42/Aβ 40 ratio threshold of 0.060.Plasma Aβ 42/Aβ 40 ratio assayed using Simoa is weakly correlated with in vivo brain amyloid and has limited accuracy in screening for amyloid positivity and for studying risk factors of brain amyloid burden when in vivo imaging is not feasible.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- amyloid; brain
- hispanics
- middle age
- plasma
- positron emission tomography
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rippon, Brady
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Palta, Priya
-
Tahmi, Mouna
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Sherwood, Greysi
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Soto, Luisa
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Cespedes, Sandin ...
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show more...
-
Mesen, Yanette
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He, Hengda
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Laing, Krystal
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Moreno, Herman
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Teresi, Jeanne
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Razlighi, Qolamr ...
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Brickman, Adam M
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Zetterberg, Henr ...
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Luchsinger, José ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg