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Plasma Cystatin C c...
Plasma Cystatin C correlates with plasma NfL levels and predicts disease progression in Parkinson's disease.
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Imarisio, Alberto (author)
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Pilotto, Andrea (author)
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Garrafa, Emirena (author)
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Conforti, Francesca (author)
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Masciocchi, Stefano (author)
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Turrone, Rosanna (author)
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Gipponi, Stefano (author)
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Cottini, Elisabetta (author)
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Rizzetti, Maria Cristina (author)
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Porrini, Vanessa (author)
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Gussago, Cristina (author)
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Pizzi, Marina (author)
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Guadagni, Fiorella (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hye, Abdul (author)
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Padovani, Alessandro (author)
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(creator_code:org_t)
- 2022-03-14
- 2021
- English.
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In: Neuro-degenerative diseases. - : S. Karger AG. - 1660-2862 .- 1660-2854. ; 21, s. 109-116
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https://doi.org/10.1...
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Abstract
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- Previous studies reported increased plasma levels of Cystatin C (Cys-C) in Parkinson's disease (PD) and claimed for a possible association with disease severity and progression. The aim of this study was to evaluate plasma Cys-C in PD and healthy controls (HC) and test its association with markers of peripheral inflammation, neurodegeneration and clinical progression in a longitudinal study.Plasma Cys-C, high-sensitive C-reactive protein (hsCRP), interleukin 6 (IL-6) and Neurofilament Light Chain (NfL) were assessed at the baseline in 71 consecutive non-demented PD and 69 HC. PD patients underwent an extensive motor and cognitive assessment at baseline and after 2 years of follow-up. The association of Cys-C with disease severity was evaluated in a multilinear model adjusted for the effect of age, sex, disease duration and peripheral inflammation.Cys-C levels appeared to be higher in PD compared to controls and correlated with the plasma neuronal marker NfL (r = 0.204, p = 0.046). In longitudinal analyses, PD patients with higher Cys-C levels exhibited faster motor progression at two years of follow-up independently from the peripheral inflammatory profile.Cys-C was associated with higher NfL levels and a remarkably faster motor progression in PD independently from peripheral inflammation. Further studies are needed in order to understand the mechanisms underpinning the association of Cys-C with higher neuronal damage markers in neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Imarisio, Albert ...
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Pilotto, Andrea
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Garrafa, Emirena
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Conforti, France ...
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Masciocchi, Stef ...
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Turrone, Rosanna
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show more...
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Gipponi, Stefano
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Cottini, Elisabe ...
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Rizzetti, Maria ...
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Porrini, Vanessa
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Gussago, Cristin ...
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Pizzi, Marina
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Guadagni, Fiorel ...
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Zetterberg, Henr ...
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Ashton, Nicholas ...
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Hye, Abdul
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Padovani, Alessa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuro-degenerati ...
- By the university
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University of Gothenburg