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Implications of ACC...
Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study FromDA VINCI.
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Vallejo-Vaz, Antonio J (author)
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Bray, Sarah (author)
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Villa, Guillermo (author)
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Brandts, Julia (author)
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Kiru, Gaia (author)
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Murphy, Jennifer (author)
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Banach, Maciej (author)
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De Servi, Stefano (author)
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Gaita, Dan (author)
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Gouni-Berthold, Ioanna (author)
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Kees Hovingh, G (author)
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Jozwiak, Jacek J (author)
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Jukema, J Wouter (author)
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Gabor Kiss, Robert (author)
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Kownator, Serge (author)
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Iversen, Helle K (author)
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Maher, Vincent (author)
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Masana, Luis (author)
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Parkhomenko, Alexander (author)
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Peeters, André (author)
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Clifford, Piers (author)
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Raslova, Katarina (author)
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Siostrzonek, Peter (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Tousoulis, Dimitrios (author)
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Vlachopoulos, Charalambos (author)
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Vrablik, Michal (author)
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Catapano, Alberico L (author)
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Poulter, Neil R (author)
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Ray, Kausik K (author)
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(creator_code:org_t)
- 2022-05-14
- 2022
- English.
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In: Cardiovascular drugs and therapy. - : Springer Science and Business Media LLC. - 1573-7241 .- 0920-3206.
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https://doi.org/10.1...
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Abstract
Subject headings
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- Low-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association (ACC/AHA) and 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) (<70 vs.<55mg/dl, respectively). In the DA VINCI study, residual cardiovascular risk was predicted in ASCVD patients. The extent to which relative and absolute risk might be lowered by achieving ACC/AHA versus ESC/EAS LDL-C recommended approaches was simulated.DA VINCI was a cross-sectional observational study of patients prescribed lipid-lowering therapy(LLT) across 18 European countries. Ten-year cardiovascular risk (CVR) was predicted among ASCVD patients receiving stabilized LLT. For patients with LDL-C≥70mg/dl, the absolute LDL-C reduction required to achieve an LDL-C of<70 or<55mg/dl (LDL-C of 69 or 54mg/dl, respectively) was calculated. Relative and absolute risk reductions (RRRs andARRs) were simulated.Of the 2039 patients, 61% did not achieve LDL-C<70mg/dl. For patients with LDL-C≥70mg/dl, median (interquartile range) baseline LDL-C and 10-year CVR were 93 (81-115) mg/dl and 32% (25-43%), respectively. Median LDL-C reductions of 24 (12-46) and 39 (27-91) mg/dl were needed to achieve an LDL-C of 69 and 54mg/dl, respectively. Attaining ACC/AHA or ESC/EAS goals resulted in simulated RRRs of 14% (7-25%) and 22% (15-32%), respectively, and ARRs of 4% (2-7%) and 6% (4-9%), respectively.In ASCVD patients, achieving ESC/EAS LDL-C goals could result in a 2% additional ARR over 10years versusthe ACC/AHA approach.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Vallejo-Vaz, Ant ...
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Bray, Sarah
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Villa, Guillermo
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Brandts, Julia
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Kiru, Gaia
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Murphy, Jennifer
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show more...
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Banach, Maciej
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De Servi, Stefan ...
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Gaita, Dan
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Gouni-Berthold, ...
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Kees Hovingh, G
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Jozwiak, Jacek J
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Jukema, J Wouter
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Gabor Kiss, Robe ...
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Kownator, Serge
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Iversen, Helle K
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Maher, Vincent
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Masana, Luis
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Parkhomenko, Ale ...
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Peeters, André
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Clifford, Piers
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Raslova, Katarin ...
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Siostrzonek, Pet ...
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Romeo, Stefano, ...
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Tousoulis, Dimit ...
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Vlachopoulos, Ch ...
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Vrablik, Michal
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Catapano, Alberi ...
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Poulter, Neil R
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Ray, Kausik K
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Cardiovascular d ...
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University of Gothenburg