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Polygenic predictio...
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Okbay, AysuVrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.,Vrije Universiteit Amsterdam (NL)
(author)
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-03-31
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Springer Science and Business Media LLC,2022
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LIBRIS-ID:oai:gup.ub.gu.se/316720
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https://gup.ub.gu.se/publication/316720URI
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https://doi.org/10.1038/s41588-022-01016-zDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485925URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149194235URI
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https://research.hhs.se/esploro/outputs/journalArticle/Polygenic-prediction-of-educational-attainment-within/991001480671706056URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Karl-Oskar Lindgren ingår i gruppen Social Science Genetic Association Consortium
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We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wu, YedaUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Wang, NancyNBER, Cambridge, MA 02138 USA.,National Bureau of Economic Research (US)
(author)
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Jayashankar, HariharanNBER, Cambridge, MA 02138 USA.,National Bureau of Economic Research (US)
(author)
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Bennett, MichaelNBER, Cambridge, MA 02138 USA.,National Bureau of Economic Research (US)
(author)
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Nehzati, Seyed MoeenUniv Calif Los Angeles, Anderson Sch Management, Los Angeles, CA 90095 USA.,UCLA Anderson School of Management
(author)
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Sidorenko, JuliaUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Kweon, HyeokmoonVrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.,Vrije Universiteit Amsterdam (NL)
(author)
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Goldman, GrantNBER, Cambridge, MA 02138 USA.,National Bureau of Economic Research (US)
(author)
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Gjorgjieva, TamaraNBER, Cambridge, MA 02138 USA.,National Bureau of Economic Research (US)
(author)
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Jiang, Yunxuan23AndMe Inc, Sunnyvale, CA USA.,23andMe
(author)
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Hicks, Barry23AndMe Inc, Sunnyvale, CA USA.,23andMe
(author)
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Tian, Chao23AndMe Inc, Sunnyvale, CA USA.,23andMe
(author)
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Hinds, David A23AndMe Inc, Sunnyvale, CA USA.,23andMe
(author)
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Ahlskog, RafaelUppsala Univ, Dept Govt, Uppsala, Sweden.,Uppsala University (SE)
(author)
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Magnusson, Patrik K EKarolinska Institutet,Karolinska Institutet (SE)
(author)
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Oskarsson, SvenUppsala Univ, Dept Govt, Uppsala, Sweden.,Uppsala University (SE)
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Hayward, CarolineUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.,University of Edinburgh
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Campbell, ArchieUniv Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Canc, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Porteous, David JUniv Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Canc, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.,Univ Calif Los Angeles, Anderson Sch Management, Los Angeles, CA 90095 USA.,University of Edinburgh,UCLA Anderson School of Management
(author)
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Freese, JeremyStanford Univ, Dept Sociol, Stanford, CA 94305 USA.,Stanford University (US)
(author)
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Herd, PamelaGeorgetown Univ, McCourt Sch Publ Policy, Washington, DC USA.,Georgetown University (US)
(author)
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Watson, ChelseaUniv Calif Los Angeles, Anderson Sch Management, Los Angeles, CA 90095 USA.,UCLA Anderson School of Management
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Jala, JonathanUniv Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA.,NBER, Cambridge, MA 02138 USA.;Univ Calif Los Angeles, Anderson Sch Management, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Human Genet Dept, Los Angeles, CA 90095 USA.,University of Minnesota Twin Cities (US),National Bureau of Economic Research (US)
(author)
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Conley, DaltonPrinceton Univ, Dept Sociol, Princeton, NJ 08544 USA.,Princeton University (US)
(author)
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Koellinger, Philipp DVrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.;Univ Wisconsin, Robert M La Follette Sch Publ Affairs, Madison, WI USA.,Vrije Universiteit Amsterdam (NL)
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Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se
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Laibson, DavidHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
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Meyer, Michelle NGeisinger Hlth Syst, Ctr Translat Bioeth & Hlth Care Policy, Danville, PA USA.,Geisinger Health System
(author)
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Lee, James J
(author)
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Kong, AugustineUniv Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England.,University of Oxford (GB)
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Yengo, LoicUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
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Cesarini, DavidNBER, Cambridge, MA 02138 USA.;NYU, Dept Econ, New York, NY 10003 USA.;NYU, Ctr Expt Social Sci, New York, NY USA.,Center for Experimental Social Science
(author)
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Turley, PatrickUniv Southern Calif, Dept Econ, Los Angeles, CA 90007 USA.;Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90007 USA.,University of Southern California (US)
(author)
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Visscher, Peter MUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
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Beauchamp, Jonathan PGeorge Mason Univ, Interdisciplinary Ctr Econ Sci, Fairfax, VA 22030 USA.;George Mason Univ, Dept Econ, Fairfax, VA 22030 USA.,George Mason University
(author)
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Benjamin, Daniel J
(author)
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Young, Alexander IUniv Calif Los Angeles, Anderson Sch Management, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Human Genet Dept, Los Angeles, CA 90095 USA.,UCLA Anderson School of Management
(author)
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Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo
(author)
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Lindgren, Karl-Oskar,1976-Uppsala universitet,Statsvetenskapliga institutionen,Social Science Genetic Association Consortium(Swepub:uu)kaoslind
(contributor)
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Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.Vrije Universiteit Amsterdam (NL)
(creator_code:org_t)
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In:Nature genetics: Springer Science and Business Media LLC54:4, s. 437-4491546-17181061-4036
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- By the author/editor
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Okbay, Aysu
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Wu, Yeda
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Wang, Nancy
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Jayashankar, Har ...
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Bennett, Michael
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Nehzati, Seyed M ...
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show more...
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Sidorenko, Julia
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Kweon, Hyeokmoon
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Goldman, Grant
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Gjorgjieva, Tama ...
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Jiang, Yunxuan
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Hicks, Barry
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Tian, Chao
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Hinds, David A
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Ahlskog, Rafael
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Magnusson, Patri ...
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Oskarsson, Sven
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Hayward, Carolin ...
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Campbell, Archie
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Porteous, David ...
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Freese, Jeremy
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Herd, Pamela
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Watson, Chelsea
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Jala, Jonathan
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Conley, Dalton
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Koellinger, Phil ...
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Johannesson, Mag ...
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Laibson, David
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Meyer, Michelle ...
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Lee, James J
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Kong, Augustine
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Yengo, Loic
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Cesarini, David
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Turley, Patrick
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Visscher, Peter ...
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Beauchamp, Jonat ...
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Benjamin, Daniel ...
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Young, Alexander ...
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Jacobsson, Bo, 1 ...
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Lindgren, Karl-O ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet
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Stockholm School of Economics