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Deficiency of SARS-...
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity.
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- Einarsdottir, Sigrun (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Martner, Anna, 1979 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Waldenström, Jesper, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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- Nicklasson, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Ringlander, Johan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Arabpour, Mohammad (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Centrum för Cancerforskning (SCCR),Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska Center for Cancer Research (SCCR),University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Törnell, Andreas, 1994 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Grauers Wiktorin, Hanna, 1990 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Institutionen för biomedicin,Department of Mathematical Sciences,Institute of Biomedicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Bittar, Rudy (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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Nilsson, Malin (author)
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- Lisak, Mikael (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Veje, Malin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Friman, Vanda, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg
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- Al-Dury, Samer (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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- Ljungman, Per (author)
- Karolinska Institutet
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- Brune, Mats, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg
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- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Centrum för Cancerforskning (SCCR),Institutionen för biomedicin, avdelningen för infektionssjukdomar,Sahlgrenska Center for Cancer Research (SCCR),Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg
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(creator_code:org_t)
- 2022-04-29
- 2022
- English.
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In: Blood advances. - : American Society of Hematology. - 2473-9537 .- 2473-9529. ; 6:9, s. 2723-2730
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Abstract
Subject headings
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- Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematological diseases are at risk of severe disease and death from COVID-19. To determine the safety and immunogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines, samples from 50 infection-naive allo-HSCT recipients (median, 92 months from transplantation, range, 7-340 months) and 39 healthy controls were analyzed for serum immunoglobulin G (IgG) against the receptor binding domain (RBD) within spike 1 (S1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; anti-RBD-S1 IgG) and for SARS-CoV-2-specific T-cell immunity, reflected by induction of T-cell-derived interferon-γ in whole blood stimulated ex vivo with 15-mer SI-spanning peptides with 11 amino acid overlapS1-spanning peptides. The rate of seroconversion was not significantly lower in allo-transplanted patients than in controls with 24% (12/50) and 6% (3/50) of patients remaining seronegative after the first and second vaccination, respectively. However, 58% of transplanted patients lacked T-cell responses against S1 peptides after 1 vaccination compared with 19% of controls (odds ratio [OR] 0.17; P = .009, Fisher's exact test) with a similar trend after the second vaccination where 28% of patients were devoid of detectable specific T-cell immunity, compared with 6% of controls (OR 0.18; P = .02, Fisher's exact test). Importantly, lack of T-cell reactivity to S1 peptides after vaccination heralded substandard levels (<100 BAU/mL) of anti-RBD-S1 IgG 5 to 6 months after the second vaccine dose (OR 8.2; P = .007, Fisher's exact test). We conclude that although allo-HSCT recipients achieve serum anti-RBD-S1 IgG against SARS-CoV-2 after 2 vaccinations, a deficiency of SARS-CoV-2-specific T-cell immunity may subsequently translate into insufficient humoral responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Antibodies
- Viral
- BNT162 Vaccine
- COVID-19
- prevention & control
- COVID-19 Vaccines
- Hematopoietic Stem Cell Transplantation
- adverse effects
- Humans
- Immunity
- Humoral
- Immunoglobulin G
- SARS-CoV-2
- Survivors
- T-Lymphocytes
- Vaccination
Publication and Content Type
- ref (subject category)
- art (subject category)
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Einarsdottir, Si ...
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Martner, Anna, 1 ...
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Waldenström, Jes ...
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Nicklasson, Mali ...
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Ringlander, Joha ...
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Arabpour, Mohamm ...
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Törnell, Andreas ...
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Grauers Wiktorin ...
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Bittar, Rudy
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Nilsson, Malin
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Lisak, Mikael
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Veje, Malin
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Friman, Vanda, 1 ...
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Al-Dury, Samer
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Bergström, Tomas ...
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Ljungman, Per
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Brune, Mats, 195 ...
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Blood advances
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University of Gothenburg
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Chalmers University of Technology
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Karolinska Institutet