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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003180naa a2200505 4500
001oai:gup.ub.gu.se/316767
003SwePub
008240528s2022 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3167672 URI
0247 a https://doi.org/10.1002/anie.2022007162 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wang, Yingu Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xwanyi
2451 0a Single-Vesicle Electrochemistry Following Repetitive Stimulation Reveals a Mechanism for Plasticity Changes with Iron Deficiency
264 c 2022-03-21
264 1b Wiley,c 2022
520 a Deficiency of iron, the most abundant transition metal in the brain and important for neuronal activity, is known to affect synaptic plasticity, causing learning and memory deficits. How iron deficiency impacts plasticity by altering neurotransmission at the cellular level is not fully understood. We used electrochemical methods to study the effect of iron deficiency on plasticity with repetitive stimulation. We show that during iron deficiency, repetitive stimulation causes significant decrease in exocytotic release without changing vesicular content. This results in a lower fraction of release, opposite to the control group, upon repetitive stimulation. These changes were partially reversible by iron repletion. This finding suggests that iron deficiency has a negative effect on plasticity by decreasing the fraction of vesicular release in response to repetitive stimulation. This provides a putative mechanism for how iron deficiency modulates plasticity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Exocytosis
653 a Chemical Release Fraction
653 a Iron Deficiency
653 a Plasticity
653 a Repetitive Stimulation
653 a long-term potentiation
653 a restless legs syndrome
653 a motor cortex
653 a excitability
653 a synaptic plasticity
653 a pc12 cells
653 a dopamine
653 a transmitters
653 a exocytosis
653 a secretion
653 a fraction
653 a Chemistry
7001 a Gu, Chaoyi,d 1992u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xgucha
7001 a Ewing, Andrew G,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology4 aut0 (Swepub:gu)xewian
7102 a Göteborgs universitetb Institutionen för kemi och molekylärbiologi4 org
7730 t Angewandte Chemie-International Editiond : Wileyg 61:21q 61:21x 1433-7851x 1521-3773
8564 8u https://gup.ub.gu.se/publication/316767
8564 8u https://doi.org/10.1002/anie.202200716

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