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Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults
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- Vidal-Pineiro, D. (author)
- University of Oslo
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Sorensen, O. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Capogna, E. (author)
- University of Oslo
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- Halaas, N. B. (author)
- University of Oslo,Oslo university hospital
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- Idland, A. V. (author)
- Oslo university hospital,University of Oslo
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- Mowinckel, A. M. (author)
- University of Oslo
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- Pereira, Joana Braga (author)
- Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Watne, L. O. (author)
- Oslo university hospital
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Sahlgrenska Academy,University College London
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- Walhovd, K. B. (author)
- University of Oslo,Oslo university hospital
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- Fjell, A. M. (author)
- Oslo university hospital,University of Oslo
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- Sørensen, Øystein (author)
- University of Oslo
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 116, s. 80-91
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Abstract
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- It is unclear whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration predict brain atrophy in cognitively healthy older adults, whether these associations can be explained by phosphorylated tau181 (p-tau) and the 42 amino acid form of amyloid-beta (A beta 42) biomarkers, and which neural substrates may drive these associations. We addressed these questions in 2 samples of cognitively healthy older adults who underwent longitudinal structural MRI up to 7 years and had baseline CSF levels of heart-type fatty-acid binding protein (FABP3) = , total-tau, neurogranin, and neurofilament light (NFL) (n = 189, scans = 721). The results showed that NFL, total-tau, and FABP3 predicted entorhinal thinning and hippocampal atrophy. Brain atrophy was not moderated by A beta 42 and the associations between NFL and FABP3 with brain atrophy were independent of p-tau. The spatial pattern of cortical atrophy associated with the biomarkers overlapped with neurogenetic profiles associated with expression in the axonal (total-tau, NFL) and dendritic (neurogranin) components. CSF biomarkers of neurodegeneration are useful for predicting specific features of brain atrophy in older adults, independently of amyloid and tau pathology biomarkers. (C) 2022 The Author(s). Published by Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Cognitively healthy older adults
- Neurodegeneration biomarkers
- FABP3
- Neurogranin
- NFL
- CSF
- serum neurofilament light
- surface-based analysis
- alzheimers-disease
- hippocampal atrophy
- association
- protein
- expression
- calcium/calmodulin
- neurogranin
- modulation
- Geriatrics & Gerontology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vidal-Pineiro, D ...
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Sorensen, O.
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Blennow, Kaj, 19 ...
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Capogna, E.
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Halaas, N. B.
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Idland, A. V.
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show more...
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Mowinckel, A. M.
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Pereira, Joana B ...
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Watne, L. O.
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Zetterberg, Henr ...
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Walhovd, K. B.
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Fjell, A. M.
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Sørensen, Øystei ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurobiology of ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Lund University