Search: onr:"swepub:oai:gup.ub.gu.se/317489" > The risk of COVID-1...
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000 | 11386naa a2202761 4500 | |
001 | oai:gup.ub.gu.se/317489 | |
003 | SwePub | |
008 | 240910s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:150513700 | |
024 | 7 | a https://gup.ub.gu.se/publication/3174892 URI |
024 | 7 | a https://doi.org/10.1073/pnas.22004131192 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1505137002 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Manry, Jérémy4 aut |
245 | 1 0 | a The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies. |
264 | c 2022-05-16 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2022 |
520 | a Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a Adult | |
653 | a Age Factors | |
653 | a Aged | |
653 | a Aged | |
653 | a 80 and over | |
653 | a Antibodies | |
653 | a Neutralizing | |
653 | a blood | |
653 | a Autoantibodies | |
653 | a blood | |
653 | a Autoimmunity | |
653 | a COVID-19 | |
653 | a immunology | |
653 | a mortality | |
653 | a Female | |
653 | a Humans | |
653 | a Interferon Type I | |
653 | a immunology | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Risk | |
653 | a SARS-CoV-2 | |
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700 | 1 | a Ekwall, Olov,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xekwol |
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710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 119:21q 119:21x 1091-6490 |
773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 119:21q 119:21x 0027-8424 |
856 | 4 8 | u https://gup.ub.gu.se/publication/317489 |
856 | 4 8 | u https://doi.org/10.1073/pnas.2200413119 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150513700 |
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