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Preclinical develop...
Preclinical development of sodium fusidate antibiotic cutaneous spray based on water-free lipid formulation system
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- Holmbäck, Jan (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK),Stockholm University, Sweden; Lipidor AB, Sweden
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- Rinwa, Vibhu (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK),Stockholm University, Sweden; Lipidor AB, Sweden
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- Håkansson, Joakim (author)
- Göteborgs universitet,RISE,Material och produktion,Gothenburg University, Sweden,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Håkansson, Joakim, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Rinwa, P. (author)
- Lipidor AB, Sweden
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- Carlsson, A. (author)
- MediGelium AB, Sweden
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- Herslof, B. (author)
- Lipidea AB, Sweden
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: European Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0928-0987 .- 1879-0720. ; 176
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Abstract
Subject headings
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- Topical antibiotics are a key component in the management of mild to moderate skin and soft tissue infections. There are, however, concerns about the emerging bacterial resistance against topical antibacterial agents such as fusidic acid, due to the prolonged treatment period of its marketed dosage forms. Improving the efficacy of topical formulations could potentially shorten the treatment period and avoid the resistance growth. To provide a more effective drug delivery, a water-free lipid-based formulation system (AKVANO (R)) which can be applied by spraying, has been developed. In the current paper, different formulations containing sodium fusidate were evaluated for their in vitro skin permeability using artificial skin mimicking membranes and antibacterial properties using ex vivo and in vivo skin wound infection models. The novel formulations containing sodium fusidate showed a much higher skin permeation (up to 60% of nominal amount) than the commercially available Fucidin (R) cream (3%). These formulations also gave a significantly stronger antibacterial effect than Fucidin cream showing a clear dose-response relationship for the sodium fusidate content. A spray product based on the described formulation technology would therefore require a shorter treatment time and thereby lower the risk for the development of bacterial resistance. Spray administration of these formulations provides an even layer on the skin surface from which the solvent quickly evaporates and thereby facilitates a non-touch application where no rubbing is required.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Topical antibiotic spray
- Bacterial resistance
- Lipid -based
- formulation
- Skin permeability
- Skin infection models
- staphylococcus-aureus
- acid
- Pharmacology & Pharmacy
- Topical antibiotic spray
Publication and Content Type
- ref (subject category)
- art (subject category)
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