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Association of plas...
Association of plasma neurofilament light chain with disease activity in chronic inflammatory demyelinating polyradiculoneuropathy
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Kapoor, M. (author)
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Carr, A. (author)
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Foiani, M. (author)
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Heslegrave, A. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Malaspina, A. (author)
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Compton, L. (author)
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Hutton, E. (author)
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Rossor, A. (author)
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Reilly, M. M. (author)
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Lunn, M. P. (author)
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(creator_code:org_t)
- 2022-07-25
- 2022
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 29:11, s. 3347-3357
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https://doi.org/10.1...
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Abstract
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- Background and purpose This study was undertaken to explore associations between plasma neurofilament light chain (pNfL) concentration (pg/ml) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and examine the usefulness of pNfL concentrations in determining disease remission. Methods We examined pNfL concentrations in treatment-naive CIDP patients (n = 10) before and after intravenous immunoglobulin (IVIg) induction treatment, in pNfL concentrations in patients on maintenance IVIg treatment who had stable (n = 15) versus unstable disease (n = 9), and in clinically stable IVIg-treated patients (n = 10) in whom we suspended IVIg to determine disease activity and ongoing need for maintenance IVIg. pNfL concentrations in an age-matched healthy control group were measured for comparison. Results Among treatment-naive patients, pNfL concentration was higher in patients before IVIg treatment than healthy controls and subsequently reduced to be comparable to control group values after IVIg induction. Among CIDP patients on IVIg treatment, pNfL concentration was significantly higher in unstable patients than stable patients. A pNFL concentration > 16.6 pg/ml distinguished unstable treated CIDP from stable treated CIDP (sensitivity = 86.7%, specificity = 66.7%, area under receiver operating characteristic curve = 0.73). Among the treatment withdrawal group, there was a statistically significant correlation between pNfL concentration at time of IVIg withdrawal and the likelihood of relapse (r = 0.72, p < 0.05), suggesting an association of higher pNfL concentration with active disease. Conclusions pNfL concentrations may be a sensitive, clinically useful biomarker in assessing subclinical disease activity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- CIDP
- disease activity
- IVIg
- neurofilament light chain
- nerve society guideline
- polyneuropathy
- immunoglobulin
- prognosis
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kapoor, M.
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Carr, A.
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Foiani, M.
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Heslegrave, A.
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Zetterberg, Henr ...
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Malaspina, A.
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show more...
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Compton, L.
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Hutton, E.
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Rossor, A.
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Reilly, M. M.
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Lunn, M. P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg