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Multi-Omics Interdi...
Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE)
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- Mavrina, E. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, KIN Ctr Digital Innovat, Amsterdam, Netherlands.
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- Kimble, L. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, KIN Ctr Digital Innovat, Amsterdam, Netherlands.
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- Waury, K. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Ctr Integrat Bioinformat, Ctr Integrat Bioinformat VU IBIVU, Dept Comp Sci, Amsterdam, Netherlands.
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- Gogishvili, D. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Ctr Integrat Bioinformat, Ctr Integrat Bioinformat VU IBIVU, Dept Comp Sci, Amsterdam, Netherlands.
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- de San Jose, N. G. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Univ Ulm, Dept Neurol, Ulm, Germany.
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- Das, S. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;ADx Neurosci, Ghent, Belgium.
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- Coppens, S. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Lab Govt Chemist LGC, Natl Measurement Lab, Teddington, England.
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- Fernandes Gomes, Bárbara (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Mölndal, Sweden.
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- Mravinacová, Sára (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands
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- Wojdala, A. L. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Univ Perugia, Dept Med & Surg, Lab Clin Neurochem, Perugia, Italy.
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- Bolsewig, K. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
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- Bayoumy, S. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
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- Burtscher, F. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Univ Luxembourg, Luxembourg Ctr Syst Biomed, Esch Sur Alzette, Luxembourg.
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- Mohaupt, P. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Univ Montpellier, Inst Regenerat Med & Biotherapy Plateforme Prote C, Inst Neurosci Montpellier INM, Inst Natl Sante & Rech Med INSERM,Ctr Hosp Univ Mo, Montpellier, France.
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- Willemse, E. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
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- Teunissen, C. (author)
- MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
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MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands;Vrije Univ Amsterdam, KIN Ctr Digital Innovat, Amsterdam, Netherlands. MIRIADE Consortium Multi Interdisciplinary Res Int, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Ctr Integrat Bioinformat, Ctr Integrat Bioinformat VU IBIVU, Dept Comp Sci, Amsterdam, Netherlands. (creator_code:org_t)
- 2022-07-12
- 2022
- English.
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In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 13
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Abstract
Subject headings
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- Proteomics studies have shown differential expression of numerous proteins in dementias but have rarely led to novel biomarker tests for clinical use. The Marie Curie MIRIADE project is designed to experimentally evaluate development strategies to accelerate the validation and ultimate implementation of novel biomarkers in clinical practice, using proteomics-based biomarker development for main dementias as experimental case studies. We address several knowledge gaps that have been identified in the field. First, there is the technology-translation gap of different technologies for the discovery (e.g., mass spectrometry) and the large-scale validation (e.g., immunoassays) of biomarkers. In addition, there is a limited understanding of conformational states of biomarker proteins in different matrices, which affect the selection of reagents for assay development. In this review, we aim to understand the decisions taken in the initial steps of biomarker development, which is done via an interim narrative update of the work of each ESR subproject. The results describe the decision process to shortlist biomarkers from a proteomics to develop immunoassays or mass spectrometry assays for Alzheimer's disease, Lewy body dementia, and frontotemporal dementia. In addition, we explain the approach to prepare the market implementation of novel biomarkers and assays. Moreover, we describe the development of computational protein state and interaction prediction models to support biomarker development, such as the prediction of epitopes. Lastly, we reflect upon activities involved in the biomarker development process to deduce a best-practice roadmap for biomarker development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- dementia
- biomarkers
- cerebrospinal fluid
- mass spectrometry
- immunoassays
- assay development
- implementation
- cerebrospinal-fluid csf
- parkinsons-disease
- alzheimers-disease
- frontotemporal dementia
- neurofilament light
- proteins
- blood
- neurodegeneration
- association
- carriers
- Neurosciences & Neurology
- dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Mavrina, E.
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Kimble, L.
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Waury, K.
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Gogishvili, D.
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de San Jose, N. ...
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Das, S.
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Coppens, S.
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Fernandes Gomes, ...
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Mravinacová, Sár ...
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Wojdala, A. L.
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Bolsewig, K.
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Bayoumy, S.
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Burtscher, F.
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Mohaupt, P.
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Willemse, E.
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Teunissen, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Frontiers in Neu ...
- By the university
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University of Gothenburg
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Royal Institute of Technology