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Plasma Neurofilamen...
Plasma Neurofilament Light and p-tau181 and Risk of Psychosis in Parkinson's Disease
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Gibson, L. L. (author)
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Pollak, T. A. (author)
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Heslegrave, A. (author)
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Hye, A. (author)
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Batzu, L. (author)
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Rota, S. (author)
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Trivedi, D. (author)
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Nicholson, T. R. (author)
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Ffytche, D. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Chaudhuri, K. R. (author)
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Aarsland, D. (author)
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(creator_code:org_t)
- IOS Press, 2022
- 2022
- English.
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In: Journal of Parkinsons Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 12:5, s. 1527-1538
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Abstract
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- Background: Neuropsychiatric symptoms are common and important to people with Parkinson's disease (PD), but their etiology is poorly understood. Plasma neurofilament light (NfL) and p-tau181 are biomarkers of neuro-axonal degeneration and tau pathology respectively, which have yet to be explored in association with the affective and psychotic symptoms in PD. Objective: To investigate the relationship between plasma NfL and p-taul 81 with the affective and psychotic symptoms in PD. Methods: We assessed the baseline concentration of plasma NfL and p-taul 81 in a cohort of 108 patients with PD and 38 healthy controls. A subgroup of patients (n = 63) were assessed annually with clinical measures for up to 7 years. Psychotic symptoms were assessed using the Non-Motor Symptom Scale and affective symptoms were measured in the Hospital Anxiety and Depression Scale. Results: Baseline plasma NfL was a significant predictor of psychotic symptoms longitudinally across the study adjusted for age, Hoehn and Yahr stage, duration of follow up, duration of disease, baseline levodopa and dopamine agonist medication, and baseline cognition: (OR 8.15 [95% CI 1.40-47.4], p =0 .020). There was no association between NfL concentration and the cumulative prevalence of affective symptoms. Plasma p-taul 81 concentration was not associated with psychotic or affective symptoms. Conclusion: These findings suggest psychotic symptoms are associated with greater neurodegeneration in PD. Further studies are needed to explore NfL as a potential biomarker for psychosis in PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Neurofilament light
- p-tau
- psychosis
- neuropsychiatric symptoms
- biomarker
- Parkinson's disease
- neuropsychiatric symptoms
- alzheimers-disease
- depression
- dementia
- scale
- association
- life
- tau
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gibson, L. L.
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Pollak, T. A.
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Heslegrave, A.
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Hye, A.
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Batzu, L.
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Rota, S.
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show more...
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Trivedi, D.
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Nicholson, T. R.
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Ffytche, D.
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Zetterberg, Henr ...
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Chaudhuri, K. R.
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Aarsland, D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Parki ...
- By the university
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University of Gothenburg