Search: onr:"swepub:oai:gup.ub.gu.se/317795" >
Rare genetic varian...
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Jang, Seon-KyeongUniversity of Minnesota
(author)
Rare genetic variants explain missing heritability in smoking.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-08-04
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/317795
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https://gup.ub.gu.se/publication/317795URI
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https://doi.org/10.1038/s41562-022-01408-5DOI
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https://lup.lub.lu.se/record/4cc76733-b522-40af-bf2b-a80714efc018URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability ([Formula: see text], 0.18-0.34). In the African ancestry samples, [Formula: see text] was estimated from 0.03 to 0.33 (s.e., 0.09-0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.
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Evans, Luke
(author)
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Fialkowski, Allison
(author)
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Arnett, Donna K
(author)
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Ashley-Koch, Allison E
(author)
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Barnes, Kathleen C
(author)
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Becker, Diane M
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Bis, Joshua C
(author)
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Blangero, John
(author)
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Bleecker, Eugene R
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Boorgula, Meher Preethi
(author)
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Bowden, Donald W
(author)
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Brody, Jennifer A
(author)
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Cade, Brian E
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Jenkins, Brenda W Campbell
(author)
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Carson, April P
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Chavan, Sameer
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Cupples, L Adrienne
(author)
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Custer, Brian
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Damrauer, Scott M
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David, Sean P
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de Andrade, Mariza
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Dinardo, Carla L
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Fingerlin, Tasha E
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Fornage, Myriam
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Freedman, Barry I
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Garrett, Melanie E
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Gharib, Sina A
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Glahn, David C
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Haessler, Jeffrey
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Heckbert, Susan R
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Hokanson, John E
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Hou, Lifang
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Hwang, Shih-Jen
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Hyman, Matthew C
(author)
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Judy, Renae
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Justice, Anne E
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Kaplan, Robert C
(author)
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Kardia, Sharon L R
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Kelly, Shannon
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Kim, Wonji
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Kooperberg, Charles
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Levy, Daniel
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Lloyd-Jones, Donald M
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Loos, Ruth J F
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Manichaikul, Ani W
(author)
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Gladwin, Mark T
(author)
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Martin, Lisa Warsinger
(author)
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Nouraie, Mehdi
(author)
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Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Meyers, Deborah A
(author)
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Montgomery, Courtney G
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North, Kari E
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Oelsner, Elizabeth C
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Palmer, Nicholette D
(author)
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Payton, Marinelle
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Peljto, Anna L
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Peyser, Patricia A
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Preuss, Michael
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Psaty, Bruce M
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Qiao, Dandi
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Rader, Daniel J
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Rafaels, Nicholas
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Redline, Susan
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Reed, Robert M
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Reiner, Alexander P
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Rich, Stephen S
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Rotter, Jerome I
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Schwartz, David A
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Shadyab, Aladdin H
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Silverman, Edwin K
(author)
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Smith, Nicholas L
(author)
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Smith, J. Gustav,1982Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmigu
(author)
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Smith, Albert VUniversity of Minnesota
(author)
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Smith, Jennifer A
(author)
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Tang, Weihong
(author)
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Taylor, Kent D
(author)
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Telen, Marilyn J
(author)
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Vasan, Ramachandran S
(author)
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Gordeuk, Victor R
(author)
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Wang, Zhe
(author)
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Wiggins, Kerri L
(author)
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Yanek, Lisa R
(author)
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Yang, Ivana V
(author)
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Young, Kendra A
(author)
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Young, Kristin L
(author)
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Zhang, Yingze
(author)
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Liu, Dajiang J
(author)
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Keller, Matthew C
(author)
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Vrieze, Scott
(author)
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University of MinnesotaKardiovaskulär forskning - hypertoni
(creator_code:org_t)
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et al.
Related titles
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In:Nature human behaviour: Springer Science and Business Media LLC6:11, s. 1577-15862397-3374
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Jang, Seon-Kyeon ...
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Evans, Luke
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Fialkowski, Alli ...
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Arnett, Donna K
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Ashley-Koch, All ...
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Barnes, Kathleen ...
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Becker, Diane M
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Bis, Joshua C
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Blangero, John
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Bleecker, Eugene ...
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Boorgula, Meher ...
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Bowden, Donald W
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Brody, Jennifer ...
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Cade, Brian E
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Jenkins, Brenda ...
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Carson, April P
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Chavan, Sameer
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Cupples, L Adrie ...
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Custer, Brian
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Damrauer, Scott ...
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David, Sean P
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de Andrade, Mari ...
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Dinardo, Carla L
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Fornage, Myriam
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Freedman, Barry ...
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Garrett, Melanie ...
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Gharib, Sina A
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Glahn, David C
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Haessler, Jeffre ...
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Heckbert, Susan ...
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Hokanson, John E
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Hou, Lifang
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Justice, Anne E
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Kaplan, Robert C
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Kim, Wonji
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Silverman, Edwin ...
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Smith, Nicholas ...
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Taylor, Kent D
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Telen, Marilyn J
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Vasan, Ramachand ...
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Gordeuk, Victor ...
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Wang, Zhe
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Wiggins, Kerri L
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Nature human beh ...
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University of Gothenburg
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Lund University