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Eano-Euracan-Sno Gu...
Eano-Euracan-Sno Guidelines on Circumscribed Astrocytic GLIOMAS, Glioneuronal and Neuronaltumors.
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Rudà, Roberta (author)
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Capper, David (author)
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Waldman, Adam D (author)
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Pallud, Johan (author)
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Minniti, Giuseppe (author)
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Kaley, Thomas J (author)
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Bouffet, Eric (author)
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Tabatabai, Ghazaleh (author)
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Aronica, Eleonora (author)
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- Jakola, Asgeir Store (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Pfister, Stefan M (author)
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Schiff, David (author)
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Lassman, Andrew B (author)
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Solomon, David A (author)
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Soffietti, Riccardo (author)
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Weller, Michael (author)
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Preusser, Matthias (author)
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Idbaih, Ahmed (author)
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Wen, Patrick Y (author)
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van den Bent, Martin J (author)
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(creator_code:org_t)
- 2022-08-01
- 2022
- English.
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In: Neuro-oncology. - : Oxford University Press (OUP). - 1523-5866 .- 1522-8517. ; 24:12, s. 2015-2034
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Abstract
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- In the new WHO 2021 Classification of CNS Tumors the chapter "Circumscribed astrocytic gliomas, glioneuronal and neuronal tumors" encompasses several different rare tumor entities, which occur more frequently in children, adolescents and young adults. The Task Force has reviewed the evidence of diagnostic and therapeutic interventions, which is low particularly for adult patients, and draw recommendations accordingly. Tumor diagnosis, based on WHO 2021, is primarily performed using conventional histological techniques; however, molecular workup is important for differential diagnosis, in particular DNA methylation profiling for the definitive classification of histologically unresolved cases. Molecular factors are increasingly of prognostic and predictive importance. MRI finding are non specific, but for some tumors are characteristic and suggestive. Gross total resection, when feasible, is the most important treatment in terms of prolonging survival and achieving long-term seizure control. Conformal radiotherapy should be considered in grade 3 and incompletely resected grade 2 tumors. In recurrent tumors reoperation and radiotherapy, including stereotactic radiotherapy, can be useful. Targeted therapies may be used in selected patients: BRAF and MEK inhibitors in pilocytic astrocytomas, pleomorphic xanthoastrocytomas, and gangliogliomas when BRAF altered, and mTOR inhibitor everolimus in subependymal giant cells astrocytomas .Sequencing to identify molecular targets is advocated for diagnostic clarification and to direct potential targeted therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Rudà, Roberta
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Capper, David
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Waldman, Adam D
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Pallud, Johan
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Minniti, Giusepp ...
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Kaley, Thomas J
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show more...
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Bouffet, Eric
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Tabatabai, Ghaza ...
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Aronica, Eleonor ...
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Jakola, Asgeir S ...
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Pfister, Stefan ...
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Schiff, David
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Lassman, Andrew ...
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Solomon, David A
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Soffietti, Ricca ...
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Weller, Michael
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Preusser, Matthi ...
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Idbaih, Ahmed
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Wen, Patrick Y
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van den Bent, Ma ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Neuro-oncology
- By the university
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University of Gothenburg