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Sensitization to mo...
Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study
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- Ermis, Özuygur, 1991 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.;Dokuz Eylul Univ, Dept Resp Med, Izmir, Turkey.
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- Borres, Magnus P, 1956- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Thermo Fisher Sci, ImmunoDiagnost, Uppsala, Sweden.
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- Basna, Rani, 1981 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Ekerljung, Linda, 1979 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Malmhäll, Carina, 1959 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Goksör, Emma, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Dept Pediat, Queen Silvia Childrens Hosp, Gothenburg, Sweden.
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- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Dept Pediat, Queen Silvia Childrens Hosp, Gothenburg, Sweden.
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- Rådinger, Madeleine, 1967 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Lötvall, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Lundbäck, Bo, 1948 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.
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- Kankaaranta, Hannu (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.;Univ Tampere, Fac Med & Life Sci, Tampere, Finland.;Seinajoki Cent Hosp, Dept Resp Med, Seinajoki, Finland.
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- Nwaru, Bright I, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Krefting Research Centre,Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Inst Med, Gothenburg, Sweden.
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(creator_code:org_t)
- 2022-09
- 2023
- English.
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In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. - : Wiley. - 0954-7894 .- 1365-2222. ; 53:1, s. 88-104
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Abstract
Subject headings
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- As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes, and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population.Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, Can f 6 using ImmunoCAPTM . Poly-sensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin, or prostatic kallikrein).Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without.Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- Can f 1
- Can f 5
- component resolved diagnostics
- dog allergy
- dog dander sensitization
- dog molecular allergen components
- furry animal allergy
- component resolved diagnostics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ermis, Özuygur, ...
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Borres, Magnus P ...
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Basna, Rani, 198 ...
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Ekerljung, Linda ...
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Malmhäll, Carina ...
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Goksör, Emma, 19 ...
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Wennergren, Göra ...
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Rådinger, Madele ...
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Lötvall, Jan, 19 ...
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Lundbäck, Bo, 19 ...
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Kankaaranta, Han ...
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Nwaru, Bright I, ...
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Clinical and exp ...
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University of Gothenburg
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Uppsala University