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Bergamot Polyphenol...
Bergamot Polyphenol Extract Reduces Hepatocyte Neutral Fat by Increasing Beta-Oxidation
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Mirarchi, A. (author)
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Mare, R. (author)
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Musolino, V. (author)
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Nucera, S. (author)
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Mollace, V. (author)
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Pujia, A. (author)
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Montalcini, T. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Maurotti, S. (author)
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(creator_code:org_t)
- 2022-08-20
- 2022
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 14:16
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Background: Bergamot polyphenolic fraction (PF) extract exerts a beneficial against liver steatosis. However, the fundamental processes underlying this beneficial effect of bergamot PF remain elusive. In this work, we examined the effect of bergamot PF extract on 2D and 3D hepatocyte cultures. Material and Methods: We evaluated the effect of bergamot PF in 2D and 3D cultures from rat, human hepatoma cells, and human primary hepatocytes. Results: In 2D cell culture, we demonstrated that incubation with bergamot PF decreases intracellular lipid content and is associated with an increase in expression levels of ss-oxidation genes (Acox1, Ppar alpha, and Ucp2) and lipophagy (Atg7). Moreover, we confirm this effect on 3D spheroids and organoids. Conclusion: Incubation with bergamot PF reduces intracellular lipid neutral fat potentially by increasing intracellular pathways related to beta-oxidation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- citrus bergamia
- human liver organoid
- NAFLD
- nutraceutical
- spheroids
- stability
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nutrients
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- By the author/editor
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Mirarchi, A.
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Mare, R.
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Musolino, V.
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Nucera, S.
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Mollace, V.
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Pujia, A.
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show more...
-
Montalcini, T.
-
Romeo, Stefano, ...
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Maurotti, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Nutrients
- By the university
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University of Gothenburg