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  • Lind, LarsUppsala universitet,Klinisk epidemiologi,Uppsala University (author)

The metabolomic profile associated with clustering of cardiovascular risk factors-A multi-sample evaluation.

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-09-15
  • Public Library of Science (PLoS),2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/318755
  • https://gup.ub.gu.se/publication/318755URI
  • https://doi.org/10.1371/journal.pone.0274701DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151393419URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485064URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-42744URI
  • https://lup.lub.lu.se/record/41838c16-0cc7-4a1a-9eb6-ec4ed7d93d11URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A clustering of cardiovascular risk factors is denoted the metabolic syndrome (MetS), but the mechanistic underpinnings of this clustering is not clear. Using large-scale metabolomics, we aimed to find a metabolic profile common for all five components of MetS.791 annotated non-xenobiotic metabolites were measured by ultra-performance liquid chromatography tandem mass spectrometry in five different population-based samples (Discovery samples: EpiHealth, n = 2342 and SCAPIS-Uppsala, n = 4985. Replication sample: SCAPIS-Malmö, n = 3978, Characterization samples: PIVUS, n = 604 and POEM, n = 501). MetS was defined by the NCEP/consensus criteria. Fifteen metabolites were related to all five components of MetS (blood pressure, waist circumference, glucose, HDL-cholesterol and triglycerides) at a false discovery rate of <0.05 with adjustments for BMI and several life-style factors. They represented different metabolic classes, such as amino acids, simple carbohydrates, androgenic steroids, corticosteroids, co-factors and vitamins, ceramides, carnitines, fatty acids, phospholipids and metabolonic lactone sulfate. All 15 metabolites were related to insulin sensitivity (Matsuda index) in POEM, but only Palmitoyl-oleoyl-GPE (16:0/18:1), a glycerophospholipid, was related to incident cardiovascular disease over 8.6 years follow-up in the EpiHealth sample following adjustment for cardiovascular risk factors (HR 1.32 for a SD change, 95%CI 1.07-1.63).A complex metabolic profile was related to all cardiovascular risk factors included in MetS independently of BMI. This profile was also related to insulin sensitivity, which provide further support for the importance of insulin sensitivity as an important underlying mechanism in the clustering of cardiovascular risk factors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi,Uppsala University(Swepub:uu)johasund (author)
  • Elmstahl, SolveLund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups(Swepub:lu)smi-sel (author)
  • Dekkers, Koen F.Uppsala universitet,Molekylär epidemiologi,Uppsala University(Swepub:uu)koede543 (author)
  • Smith, J. Gustav,1982University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University, Gothenburg, Sweden.;Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.;Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine(Swepub:lu)med-gvs (author)
  • Engstrom, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Fall, Tove,1979-Uppsala universitet,Molekylär epidemiologi,Uppsala University(Swepub:uu)tovfa878 (author)
  • Ärnlöv, Johan,1970-Karolinska Institute,Dalarna University College,Högskolan Dalarna,Karolinska Institutet,Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, Sweden,Medicinsk vetenskap(Swepub:du)jan (author)
  • Uppsala universitetKlinisk epidemiologi (creator_code:org_t)

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  • In:PloS one: Public Library of Science (PLoS)17:91932-6203

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