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Repeated Measures o...
Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke: AFFINITY Study Findings
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Chye, A. (author)
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Hackett, M. L. (author)
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Hankey, G. J. (author)
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Lundstrom, E. (author)
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Almeida, O. P. (author)
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Gommans, J. (author)
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Dennis, M. (author)
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Jan, S. (author)
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Mead, G. E. (author)
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Ford, A. H. (author)
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Beer, C. E. (author)
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Flicker, L. (author)
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Delcourt, C. (author)
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Billot, L. (author)
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Anderson, C. S. (author)
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- Stibrant Sunnerhagen, Katharina, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Yi, Q. L. (author)
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Bompoint, S. (author)
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Nguyen, T. H. (author)
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Lung, T. (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- English.
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In: Journal of the American Heart Association (JAHA). - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 11:16
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trial. METHODS AND RESULTS: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model. CONCLUSIONS: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cerebrovascular disease
- functional outcomes
- modified Rankin Scale
- partial proportional odds
- repeated measures
- stroke
- ischemic-stroke
- disability
- outcomes
- recommendations
- rehabilitation
- association
- validation
- prediction
- trials
- Cardiovascular System & Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chye, A.
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Hackett, M. L.
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Hankey, G. J.
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Lundstrom, E.
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Almeida, O. P.
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Gommans, J.
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show more...
-
Dennis, M.
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Jan, S.
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Mead, G. E.
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Ford, A. H.
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Beer, C. E.
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Flicker, L.
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Delcourt, C.
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Billot, L.
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Anderson, C. S.
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Stibrant Sunnerh ...
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Yi, Q. L.
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Bompoint, S.
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Nguyen, T. H.
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Lung, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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University of Gothenburg