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Repeated Measures o...
Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke: AFFINITY Study Findings
- Article/chapterEnglish2022
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Ovid Technologies (Wolters Kluwer Health),2022
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LIBRIS-ID:oai:gup.ub.gu.se/318805
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https://gup.ub.gu.se/publication/318805URI
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https://doi.org/10.1161/jaha.121.025425DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trial. METHODS AND RESULTS: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model. CONCLUSIONS: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value.
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Hackett, M. L.
(author)
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Hankey, G. J.
(author)
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Lundstrom, E.
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Almeida, O. P.
(author)
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Gommans, J.
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Dennis, M.
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Jan, S.
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Mead, G. E.
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Ford, A. H.
(author)
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Beer, C. E.
(author)
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Flicker, L.
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Delcourt, C.
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Billot, L.
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Anderson, C. S.
(author)
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Stibrant Sunnerhagen, Katharina,1957Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xstika
(author)
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Yi, Q. L.
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Bompoint, S.
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Nguyen, T. H.
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Lung, T.
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
(creator_code:org_t)
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In:Journal of the American Heart Association (JAHA): Ovid Technologies (Wolters Kluwer Health)11:162047-9980
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Chye, A.
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Hackett, M. L.
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Hankey, G. J.
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Lundstrom, E.
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Almeida, O. P.
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Gommans, J.
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show more...
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Dennis, M.
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Jan, S.
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Mead, G. E.
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Ford, A. H.
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Beer, C. E.
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Flicker, L.
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Delcourt, C.
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Billot, L.
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Anderson, C. S.
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Stibrant Sunnerh ...
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Yi, Q. L.
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Bompoint, S.
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Nguyen, T. H.
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Lung, T.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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University of Gothenburg