Search: onr:"swepub:oai:gup.ub.gu.se/318818" >
Outcomes of relapse...
Outcomes of relapsed/refractory diffuse large B-cell lymphoma and influence of chimaeric antigen receptor T trial eligibility criteria in second line-A population-based study of 736 patients
-
- Harrysson, S. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
-
- Eloranta, S. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
-
- Ekberg, Sara (author)
- Karolinska Institutet,Karolinska Institute
-
show more...
-
- Enblad, Gunilla (author)
- Uppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- El-Galaly, T. C. (author)
- Karolinska Institutet,Karolinska Institute,Aalborg University Hospital
-
- Sander, B. (author)
- Karolinska Institutet
-
- Sonnevi, K. (author)
- Karolinska Institutet
-
- Andersson, Per-Ola, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Hematol, Borås, Sweden.;Gothenburg Univ, Sahlgrenska Acad, Gothenburg, Sweden.,Sahlgrenska Academy
-
- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund
-
Smedby, K. E. (author)
-
show less...
-
(creator_code:org_t)
- 2022-04-25
- 2022
- English.
-
In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 198:2, s. 267-277
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Several recently published trials investigate novel therapies for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). To estimate the benefit of these therapies in the real-world setting, comprehensive data on patients treated in clinical routine are needed. We report outcomes for 736 R/R DLBCL patients identified among all curatively treated DLBCL patients in Sweden in the period 2007-2014. Survival and associations with disease characteristics, second-line treatment and fulfilment of chimaeric antigen receptor (CAR) T-cell trial criteria were assessed. Median overall survival (OS) was 6.6 months (<= 70 years 9.6 months, >70 years 4.9 months). Early relapse (<= 12 months) was strongly associated with selection of less intensive treatment and poor survival. Among patients of at most 70 years of age, 63% started intensive second-line treatment and 34% received autologous stem cell transplantation (ASCT). Two-year OS among transplanted patients was 56% (early relapse <= 12 months 40%, late relapse >12 months 66%). A minority of patients 76 years (n = 178/506, 35%) fitted CAR T trial criteria. Median progression-free survival (PFS) for patients with early relapse fitting trial criteria was 4.8 months. In conclusion, most R/R DLBCL manifest early and are often ineligible for or cannot complete intensive regimens resulting in dismal survival. Real-world patients eligible for CAR T trials also did poorly, providing a benchmark for efficacy of novel therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- clinical research
- epidemiology
- non-Hodgkin lymphoma
- stem cell
- transplantation
- tumour immunotherapy
- chemotherapy plus rituximab
- predict survival
- chop
- transplantation
- failure
- classification
- multicenter
- therapy
- impact
- Hematology
- clinical research
- stem cell transplantation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Harrysson, S.
-
Eloranta, S.
-
Ekberg, Sara
-
Enblad, Gunilla
-
El-Galaly, T. C.
-
Sander, B.
-
show more...
-
Sonnevi, K.
-
Andersson, Per-O ...
-
Jerkeman, Mats
-
Smedby, K. E.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
British Journal ...
- By the university
-
University of Gothenburg
-
Uppsala University
-
Lund University
-
Karolinska Institutet