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Plasma p-tau231 and...
Plasma p-tau231 and p-tau217 as state markers of amyloid-beta pathology in preclinical Alzheimer's disease
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-08-11
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/318909
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https://gup.ub.gu.se/publication/318909URI
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https://doi.org/10.1038/s41591-022-01925-wDOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A comprehensive comparison of Alzheimer's disease blood biomarkers in cognitively unimpaired individuals reveals that plasma p-tau231 and p-tau217 capture very early A beta changes, showing promise as markers to enrich a preclinical population for Alzheimer's disease clinical trials Blood biomarkers indicating elevated amyloid-beta (A beta) pathology in preclinical Alzheimer's disease are needed to facilitate the initial screening process of participants in disease-modifying trials. Previous biofluid data suggest that phosphorylated tau231 (p-tau231) could indicate incipient A beta pathology, but a comprehensive comparison with other putative blood biomarkers is lacking. In the ALFA+ cohort, all tested plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL and A beta 42/40) were significantly changed in preclinical Alzheimer's disease. However, plasma p-tau231 reached abnormal levels with the lowest A beta burden. Plasma p-tau231 and p-tau217 had the strongest association with A beta positron emission tomography (PET) retention in early accumulating regions and associated with longitudinal increases in A beta PET uptake in individuals without overt A beta pathology at baseline. In summary, plasma p-tau231 and p-tau217 better capture the earliest cerebral A beta changes, before overt A beta plaque pathology is present, and are promising blood biomarkers to enrich a preclinical population for Alzheimer's disease clinical trials.
Subject headings and genre
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
(author)
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Shekari, M.
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Salvado, G.
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Ortiz-Romero, P.
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Montoliu-Gaya, LaiaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xmonla
(author)
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Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan
(author)
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Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
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Lantero Rodriguez, JuanGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xrodri
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Vanmechelen, E.
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Day, T. A.
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Gonzalez-Escalante, A.
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Sanchez-Benavides, G.
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Minguillon, C.
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Fauria, K.
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Molinuevo, J. L.
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Dage, J. L.
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
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Gispert, J. D.
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Suarez-Calvet, M.
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Göteborgs universitetWallenberg Centre for Molecular and Translational Medicine
(creator_code:org_t)
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In:Nature Medicine: Springer Science and Business Media LLC28, s. 1797-18011078-89561546-170X
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Mila-Aloma, M.
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Ashton, Nicholas ...
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Shekari, M.
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Salvado, G.
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Ortiz-Romero, P.
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Montoliu-Gaya, L ...
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Lessa Benedet, A ...
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Karikari, Thomas
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Lantero Rodrigue ...
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Vanmechelen, E.
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Day, T. A.
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Gonzalez-Escalan ...
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Sanchez-Benavide ...
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Minguillon, C.
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Fauria, K.
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Molinuevo, J. L.
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Dage, J. L.
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Zetterberg, Henr ...
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Gispert, J. D.
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Suarez-Calvet, M ...
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Blennow, Kaj, 19 ...
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- NATURAL SCIENCES
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Nature Medicine
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University of Gothenburg