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Assignment of IVL-M...
Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL(3) domain in solution
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- Han, X. (author)
- Karolinska Institutet
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- Levkovets, Maria, 1999 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Lesovoy, D. (author)
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- Sun, R. H. (author)
- Karolinska Institutet
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- Wallerstein, Johan, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Sandalova, T. (author)
- Karolinska Institutet
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- Agback, T. (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- Achour, A. (author)
- Karolinska Institutet
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- Agback, Peter (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences
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- Orekhov, Vladislav, 1966 (author)
- Gothenburg University,Göteborgs universitet,Svenskt NMR-centrum vid Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Swedish NMR Centre at Göteborg University,Department of Chemistry and Molecular Biology
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(creator_code:org_t)
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- 2022-09-12
- 2022
- English.
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In: Biomolecular Nmr Assignments. - : Springer Science and Business Media LLC. - 1874-2718 .- 1874-270X. ; 16:2, s. 363-371
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Abstract
Subject headings
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- Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contrast to other signalling mediators, MALT1 is not only activated through the formation of the CBM complex together with the proteins CARMA1 and Bcl10, but also by acting as a protease that cleaves multiple substrates to promote lymphocyte proliferation and survival via the NF-kappa B signalling pathway. Herein, we present the partial H-1, C-13 Ile/Val/Leu-Methyl resonance assignment of the monomeric apo form of the paracaspase-IgL(3) domain of human MALT1. Our results provide a solid ground for future elucidation of both the three-dimensional structure and the dynamics of MALT1, key for adequate development of inhibitors, and a thorough molecular understanding of its function(s).
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- MALT1
- Paracaspase
- H-1
- C-13 Ile
- Val
- Leu-Methyl resonance
- t-cell
- nmr-spectroscopy
- protease activity
- activation
- lymphoma
- proteins
- trosy
- relaxation
- responses
- complex
- Biophysics
- Spectroscopy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Han, X.
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Levkovets, Maria ...
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Lesovoy, D.
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Sun, R. H.
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Wallerstein, Joh ...
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Sandalova, T.
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show more...
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Agback, T.
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Achour, A.
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Agback, Peter
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Orekhov, Vladisl ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Biomolecular Nmr ...
- By the university
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University of Gothenburg
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Swedish University of Agricultural Sciences
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Karolinska Institutet