Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease

• Introduction This increasing body of literature indicates that menopause hormonal replacement therapy (MHT) may substantially mitigate the risk of developing late-life cognitive decline due to progressive Alzheimer's disease (AD) pathophysiology. For the first time, we investigated the question whether MHT impacts AD biomarker-informed pathophysiological dynamics in de-novo diagnosed menopausal women. Methods We analyzed baseline and longitudinal differences between MHT-taking and -not women in terms of concentrations of core pathophysiological AD plasma biomarkers, validated in symptomatic and cognitively healthy individuals, including biomarkers of (1) the amyloid-beta (A beta) pathway, (2) tau pathophysiology, (3) neuronal loss, and (4) axonal damage and neurodegeneration. Results We report a prominent and significant treatment response at the A beta pathway biomarker level. Women at genetic risk for AD (APOE e4 allele carriers) have particularly shown favorable results from treatment. Discussion To our knowledge, we present first prospective clinical evidence on effects of MHT on AD pathophysiology during menopause.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

mild cognitive impairment

sex-differences

postmenopausal women

apolipoprotein-e

older-adults

estrogen

risk

health

age

individuals

Neurosciences & Neurology

Publication and Content Type

ref (subject category)

art (subject category)