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IgA rheumatoid fact...
IgA rheumatoid factor in rheumatoid arthritis
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- Van Hoovels, L. (author)
- Katholieke Univ Leuven, Belgium; Onze Lieve Vrouw Hosp, Belgium
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- Vander Cruyssen, B. (author)
- Onze Lieve Vrouw Hosp, Belgium
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- Sieghart, D. (author)
- Med Univ Vienna, Austria
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- Bonroy, C. (author)
- Univ Ghent, Belgium; Univ Ghent, Belgium
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- Nagy, E. (author)
- Natl Inst Locomotor Dis & Disabil, Hungary
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- Pullerits, Rille, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Univ Hosp Gothenburg, Sweden; Univ Gothenburg, Sweden
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- Cucnik, S. (author)
- Univ Med Ctr Ljubljana, Slovenia
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- Dahle, Charlotte (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Heijnen, I. (author)
- Univ Hosp Basel, Switzerland
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- Bernasconi, L. (author)
- Kantonsspital Aarau, Switzerland
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- Benkhadra, F. (author)
- Ctr Hosp Luxembourg, Luxembourg
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- Bogaert, L. (author)
- Onze Lieve Vrouw Hosp, Belgium
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- Van den Bremt, S. (author)
- Onze Lieve Vrouw Hosp, Belgium
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- Van Liedekerke, A. (author)
- AZ Sint Elisabeth, Belgium
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- Vanheule, G. (author)
- AZ Rivierenland, Belgium
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- Robbrecht, J. (author)
- AZ Sint Lucas, Belgium
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- Studholme, L. (author)
- Natl Inst Biol Stand & Control NIBSC, England
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- Wirth, C. (author)
- Ctr Hosp Luxembourg, Luxembourg
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- Muller, R. (author)
- Rheumazentrum Ostschweiz, Switzerland
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- Kyburz, D. (author)
- Univ Hosp Basel, Switzerland
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- Sjöwall, Christopher (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Jese, R. (author)
- Univ Med Ctr Ljubljana, Slovenia
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- Jovancevic, Boja (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sweden
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- Kiss, E. (author)
- Natl Inst Locomotor Dis & Disabil, Hungary
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- Jacques, P. (author)
- Univ Hosp Ghent, Belgium; Univ Hosp Ghent, Belgium
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- Aletaha, D. (author)
- Med Univ Vienna, Austria
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- Steiner, G. (author)
- Med Univ Vienna, Austria; Ludwig Boltzmann Inst Arthrit & Rehabil, Austria
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- Verschueren, P. (author)
- Univ Hosp Leuven, Belgium; Univ Hosp Leuven, Belgium
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- Bossuyt, X. (author)
- Katholieke Univ Leuven, Belgium; Univ Hosp Leuven, Belgium
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(creator_code:org_t)
- 2022-07-06
- 2022
- English.
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In: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter GmbH. - 1434-6621 .- 1437-4331. ; 60:10, s. 1617-1626
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Objectives Rheumatoid factor (RF) is a well-established marker for the diagnosis and classification of rheumatoid arthritis (RA). Most studies evaluated IgM RF or isotype-nonspecific total RF assays. We evaluated the added value of IgA RF in this context. Methods An international sample cohort consisting of samples from 398 RA patients and 1073 controls was tested for IgA RF with 3 commercial assays. For all RA patients and 100 controls essential clinical and serological data for ACR/EULAR classification were available. Results The sensitivity of IgA RF for diagnosing RA was lower than the sensitivity of IgM RF. Differences in numerical values between IgA RF assays were observed. With all assays, the highest IgA RF values were found in patients with primary Sjogren's syndrome. Double positivity for IgM RF and IgA RF had a higher specificity for RA than either IgM RF or IgA RF. The sensitivity of double positivity was lower than the sensitivity of either IgA RF or IgM RF. Single positivity for IgA RF was at least as prevalent in controls than in RA patients. Adding IgA RF to IgM RF and anti-citrullinated protein antibodies (ACPA) did not affect RA classification. However, combined positivity for IgA RF, IgM RF and IgG ACPA had a higher specificity and lower sensitivity for RA classification than positivity for either of the antibodies. Conclusions IgA RF showed a lower sensitivity than IgM RF. Combining IgA RF with IgM RF and ACPA did not improve sensitivity of RA classification. Combined positivity (IgA-RF/IgM-RF/ACPA) increased specificity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- area under the receiver operating characteristics curve
- harmonization
- isotype
- likelihood ratio
- rheumatoid arthritis
- rheumatoid factor
- cyclic citrullinated peptide
- factor isotypes
- antibodies
- classification
- specificity
- diagnosis
- responses
- criteria
- predict
- Medical Laboratory Technology
- area under the receiver operating characteristics curve; harmonization; isotype; likelihood ratio; rheumatoid arthritis; rheumatoid factor
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Van Hoovels, L.
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Vander Cruyssen, ...
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Sieghart, D.
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Bonroy, C.
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Nagy, E.
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Pullerits, Rille ...
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show more...
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Cucnik, S.
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Dahle, Charlotte
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Heijnen, I.
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Bernasconi, L.
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Benkhadra, F.
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Bogaert, L.
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Van den Bremt, S ...
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Van Liedekerke, ...
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Vanheule, G.
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Robbrecht, J.
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Studholme, L.
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Wirth, C.
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Muller, R.
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Kyburz, D.
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Sjöwall, Christo ...
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Kastbom, Alf
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Jese, R.
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Jovancevic, Boja
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Kiss, E.
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Jacques, P.
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Aletaha, D.
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Steiner, G.
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Verschueren, P.
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Bossuyt, X.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Clinical Chemist ...
- By the university
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University of Gothenburg
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Linköping University